Citric Acid → Trisodium citrate

HRID 1254976

Reaction equation

HRID 1254976 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][C@H:5]([O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=12)[C:6]1[S:10][CH:9]=[CH:8][CH:7]=1.[C:22]([OH:34])(=[O:33])[CH2:23][C:24]([CH2:29][C:30]([OH:32])=[O:31])([C:26]([OH:28])=[O:27])[OH:25].C(=O)([O-])[O-].[K+:39].[K+].O.C(=O)(O)[O-].[Na+:46]>>[CH3:1][NH:2][CH2:3][CH2:4][C@H:5]([O:11][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=12)[C:6]1[S:10][CH:9]=[CH:8][CH:7]=1.[C:22]([O-:34])(=[O:33])[CH2:23][C:24]([CH2:29][C:30]([O-:32])=[O:31])([C:26]([O-:28])=[O:27])[OH:25].[Na+:46].[Na+:46].[Na+:46].[C:22]([O-:34])(=[O:33])[CH2:23][C:24]([CH2:29][C:30]([O-:32])=[O:31])([C:26]([O-:28])=[O:27])[OH:25].[K+:39].[K+:39].[K+:39]

Participants

8

Reactant 5

HCID 311Citric AcidHCID 962WaterHCID 11430Potassium CarbonateHCID 60835Duloxetine3×HCID 516892Sodium Bicarbonate

Product 3

HCID 6224Trisodium citrateHCID 13344Tripotassium citrateHCID 60835Duloxetine

Procedure

Effervescent Tablets and Granules were prepared using standards techniques known to persons skilled in the art. For Example: From one 20 mg duloxetine capsule, granules were emptied into mortar and pestle to prepare fine powder. A homogeneous mixture of effervescent duloxetine powder was obtained by diluting the above powdered duloxetine with about 958 mg sodium bicarbonate USP, about 832 mg citric acid USP and about 312 mg potassium carbonate USP. This powder reacted with the 60 ml water to create effervescence resulting in a bubbling solution of duloxetine with sodium citrate and potassium citrate as principal antacids.

Workup

  1. customEffervescent Tablets and Granules were prepared
  2. customto prepare fine powder
  3. customwas obtained

Sources & evidence

ORD record
ord-c1e0bdc38786428cb71a7fe903e7ed79
Source dataset
uspto-grants-2013_06
Patent number
US08455667B2

Linked notes

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