Methyltrimethoxysilane

Liquid; Liquid; Other Solid; CBI

Colorless liquid; [Sigma-Aldrich MSDS]

This chemical does not meet GHS hazard criteria for 1.7% (22 of 1271) of reports.

Danger

H225 (97.6%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P272, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1271 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Chemical: Silane, trimethoxymethyl-

Silane, trimethoxymethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Silane, trimethoxymethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 17-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14707

Silane, trimethoxymethyl-: Does not have an individual approval but may be used under an appropriate group standard

Shown to be a skin sensitizer in guinea pigs using a modified Buehler method at 25% in PEG 300 without adjuvant (grade 1 skin reactions in 30% and 20% of the animals after 24 and 48 hours, respectively); [EPA - TSCATS] A mild skin and eye irritant; [RTECS] An eye irritant; [Sigma-Aldrich MSDS] 1185-55-3 AND (sensitizer OR sensitization OR allergic): no results; [PubMed] See Trimethoxysilane and Methyl silicate.

Flam. Liq. 2 (97.6%)

Flam. Liq. 2 (33.3%)

Flammable liquids - Category 2

35 [mg/m3]

390 [mg/m3]

2300 [mg/m3]

The No Observed Adverse Effect Level (NOAEL) of 100 ppm (557 mg/m3) from the 90-day inhalation rat study was considered the point of departure for the health-based Workplace Environmental Exposure Limit (WEEL) derivation. After adjusting for duration of exposure and interindividual variability, the 8-hour Time-Weighted Average (TWA) WEEL value of 10 ppm (55 mg/m3) is fully expected to provide a significant margin of safety against potential adverse health effects in workers.

Studies showed a low order of acute toxicity for MTMS. MTMS was slightly irritating to both eyes and skin in rabbits, and a weight of evidence assessment supports that MTMS is not a dermal sensitizer. In vitro and in vivo assays indicated MTMS has a low potential for genotoxicity. MTMS did not produce any changes in reproductive or developmental parameters in a rat study. In a 90-day inhalation study in rats, MTMS was associated with urinary bladder epithelial hyperplasia, calculi formation, and moderate kidney dilation with hyperplasia of the pelvic epithelium and granulomatous inflammation; however, an expert panel review concluded that changes in the bladder and kidney were adaptive responses to a physical or chemical irritant present within the urine and were not considered to represent a preneoplastic change.

Used in household products for conditioning and waterproofing leather; [REPROTOX]

The uses of Methyltrimethoxysilane (MTMS) include as a coupling agent in thermoplastics and thermosetting resins, a cross-linker in silicone sealants, a water repellent component, and in silicone hard-coats for plastics.

Petrochemical Manufacturing

Silane, trimethoxymethyl-: ACTIVE