HuagongsheHuagongshe Chemistry Print Report · For research reference only
Antimony pentoxide
ANTIMONY OXIDE · ANTIMONY PENTOXIDE · ANTIMONY (V) OXIDE · a1550 · a2550 · ago40 · apoxs · hfr201
Identifiers & Physical Properties
| CAS No. | 1314-60-9 |
|---|---|
| Molecular formula | O5Sb2 |
| Average molar mass | 323.52 g/mol |
| Monoisotopic mass | 321.7822045 g/mol |
| SMILES | [O]=[Sb](=[O])[O][Sb](=[O])=[O] |
| InChIKey | LJCFOYOSGPHIOO-UHFFFAOYSA-N |
| PubChem CID | 14813 |
| EC No. | 215-237-7 |
| DTXSID | DTXSID6050467 |
Chemical & Physical Properties
| Topological polar surface area | 77.5 |
|---|---|
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 5 |
| Rotatable bonds | 0 |
| Heavy atoms | 7 |
| Formal charge | 0 |
| Complexity | 123 |
| Chemical classes | Metals -> Metalloid Compounds (Antimony) |
| Physical Description | CBIDry PowderLiquidOther SolidYellow solid[Merck Index] |
| Melting point | 380 °C (dec.)(lit.) |
| Density | 3.78 g/mL at 25 °C(lit.) |
| Physical state | Powder |
| Specific gravity | 3.8 |
| Color | Yellow |
| Solubility | Slightly soluble in water. Slowly dissolves in warm HCl and warm KOH. Insoluble in HNO<sub>3</sub> |
| Merck | 14,698 |
| crystal system | Monoclinic |
| Space group | C2/c |
| Lattice constant | a/nm |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Target organs | Respiratory system |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard symbols | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
| UN transport number | 1549 |
| Water hazard class (WGK) | 3 |
| RTECS number | CC6300000 |
| TSCA inventory status | TSCA listed |
| Hazard class | 6.1Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Packing group | III |
| Storage class | 11 - Combustible Solids |
| Toxicity | LD50 i.p. in rats: 400.0 mg Sb/100 g (Bradley, Fredrick) |
| REACH registrations | Active |
Safety & Regulations
| GHS classification | This chemical does not meet GHS hazard criteria for 32.5% (292 of 898) of reports.WarningH302 (54.9%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 898 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] |
|---|---|
| Regulatory information | Chemical: Antimony oxide (Sb2O5)Antimony oxide (Sb2O5) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Antimony oxide (Sb2O5) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 20-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/16264Antimony oxide: Does not have an individual approval but may be used under an appropriate group standard |
| Hazards summary | Intraperitoneal LD50 (mouse) = 978 mg/kg[RTECS] Does not fully correspond to Sb2-O5 and is always somewhat hydrated[Merck Index] A skin and strong eye irritant[Sigma-Aldrich MSDS] See Antimony and linked occupational diseases. |
| Hazard Classes and Categories | Acute Tox. 4 (54.9%)Hazardous to the aquatic environment (Acute) - Category 3 |
| Threshold Limit Values (TLV) | 0.5 [mg/m3], as Sb |
| Permissible Exposure Limit (PEL) | 0.5 [mg/m3], as Sb |
| Immediately Dangerous to Life or Health (IDLH) | 50.0 [mg/m3], as Sb |
| Treatment | Following oral exposure to antimony, administer charcoal as a slurry (240 mL water/30 g charcoal). Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (T36) |
| Health effects | Dermal exposure to antimony can cause antimony spots (papules and pustules around sweat and sebaceous glands). Antimony poisoning can also lead to pneumoconiosis. Alterations in pulmonary function and other effects including chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation can result from inhalation of antimony. Increased blood pressure can also result from antimony poisoning. Myocardial depression, vasodilation and fluid loss may cause shock with hypotension, electrolyte disturbances and acute renal failure. Cerebral oedema, coma, convulsions, and death are possible. (L741) |
| Exposure routes | Inhalation (L741)oral (L741)dermal (L741) |
| Toxicity summary | The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The mechanism of action of antimony remains unclear. However, some studies suggest that antimony combines with sulfhydryl groups including those in several enzymes important for tissue respiration. The antidotal action of BAL depends on its ability to prevent or break the union between antimony and vital enzymes. Moreover, the The cause of death is believed to be essentially the same as that in acute arsenic poisoning. Antimony pentoxide might enhance the rate of heme degradation in liver and kidney. (A240, T18, L741, A238) |
| Signs and Symptoms | Abdominal pain, vomiting, diarrhea can result from inhalation of antimony. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Skin or eye contact can cause pain and redness of the exposed surface. (T64, L741) |
| Carcinogen Classification | No indication of carcinogenicity (not listed by IARC). (L135) |
| Toxicity Data | LD50: 4000 mg/kg (Oral, Rat) (L790) LD50: 978 mg/kg (Oral, Mice) (L790) |
| RAIS Toxicity Values | 0.0005HEAST Current |
| Hazard Quotient Level 0.1 or Cancer Risk Level 1E-06 | 3.90e+015.80e+029.70e+006.00e+005.00e-04Volatile |
| Hazard Quotient Level 3 or Cancer Risk Level 1E-04 | 1.20e+021.80e+032.90e+016.00e+005.00e-04Volatile |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| RTECS number | CC6300000 |
| UN transport number | 1549 |
| Toxicity | LD50 i.p. in rats: 400.0 mg Sb/100 g (Bradley, Fredrick) |
| Risk statements (R) | 36/37/38 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi |
| Safety statements (S) | 26-36 |
| Hazard class | 6.1Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
| Storage class | 11 - Combustible Solids |
| Packing group | III |
| Target organs | Respiratory system |
| GHS hazard statements | H315-H319-H335 |
| REACH registrations | Active |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Applications & Uses
Uses
It is used as flame retardants in acrylonitrile-butadiene-styrene (ABS) polymer, plastics, rubbers, paper and textiles. It finds use as a flocculant in the production of titanium dioxide. It also finds use in ion-exchange resin. It is also employed as catalyst in certain polymerization and oxidation reactions.
Uses
Fire retardant in clothing.
Uses
Antimony pentoxide (Sb2O3) is used as a flame retardant for textile materials and as a source to prepare other antimony compounds.
Preparation & Synthesis
Preparation
The hydrated oxide is prepared by hydrolysis of antimony pentachloride; or by acidification of potassium hexahydroxoantimonate(V), KSb(OH)6 [12208- 13-8]. The product, filtered and air dried at ambient temperature has approximate composition Sb2O5 3.5H2O. It may be also prepared by oxidation of antimony trioxide with nitric acid.