Basic information
- CAS
1603-41-4- Standard SMILES
Cc1ccc(N)nc1- InChIKey
CMBSSVKZOPZBKW-UHFFFAOYSA-N- Molecular formula
- C6H8N2
- Average molar mass
- 108.14 g/mol
- Monoisotopic mass
- 108.06874826
Overview
structure in first source
Names & identifiers
- Preferred name
- 2-Amino-5-methylpyridine
- IUPAC
- 5-methylpyridin-2-amine
- English name
- 2-Amino-5-methylpyridine
- Molecular formula
- C6H8N2
- Molecular weight
- 108.14
Names & synonyms
2-Amino-5-methylpyridine1603-41-42-Pyridinamine, 5-methyl-6-Amino-3-methylpyridine5-Methyl-2-aminopyridineDTXSID40292208UM54T43WTNSC-1489NSC-96444DTXCID909220RefChem:540222216-503-5
Show more names
Perfenidone Impurity 2Pyridine, 2-amino-5-methylNSC 1489NSC 96444AKOS 91156Compound Fr142936-amino-3-picolin
5-METHYLPYRIDIN-2-AMINE6-Amino-3-picoline2-AMINO-5-PICOLINE5-Methyl-2-pyridinamine3-Picoline, 6-amino-5-Methyl-2-pyridylamine5-methylpyridin-2-ylaminePirfenidone EP Impurity A
Database identifiers
- CAS
1603-41-4- PubChem CID
- 15348
- DTXSID
DTXSID4029220- ChEMBL
CHEMBL61990- UNII
- 8UM54T43WT
- EC Number
- 216-503-5
- Nikkaji
- J31.383A
Properties
Computed structural properties
- XLogP
- 1
- Topological polar surface area
- 38.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 72.9
Experimental & physicochemical properties
SpringerMaterials PropertiesNuclear quadrupole resonance spectroscopy
LogP1.02
Physicochemical properties
- Melting point
- 76 · 76-77 °C(lit.)
- Boiling point
- 227 °C · 227 °C(lit.)
- Density
- 227 · 227
- vapor pressure
- 3.706 Pa · 3.706Pa at 25℃
- refractive index
- 1 · 1,524-1,528
- Flash point
- 118 °C · 118°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- 1000 g/l · 1000g/l
- form
- Crystalline Powder, Crystals or Flakes
- pka
- 1 · pK1: 7.22(+1) (25°C)
- color
- White to light yellow
- Sensitive
- Hygroscopic
- BRN
- 107050 · 107050
- InChI
- 1S/C6H8N2/c1-5-2-3-6(7)8-4-5/h2-4H,1H3,(H2,7,8)
- InChIKey
- CMBSSVKZOPZBKW-UHFFFAOYSA-N
- SMILES
- Cc1ccc(N)nc1
- LogP
- 1.08 · 1.08
- CAS DataBase Reference
- 1603 · 1603-41-4(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 8 UM54T43WT · 8UM54T43WT
- NIST Chemistry Reference
- 2 · 2-Pyridinamine, 5-methyl-(1603-41-4)
- EPA Substance Registry System
- 6 · 6-Amino-3-picoline (1603-41-4)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 6 · GHS06
- Signal word
- Danger
- Hazard statements
- 301 · H301+H311-H315-H319-H335
- Precautionary statements
- 280 · P280-P301+P310+P330-P302+P352+P312-P305+P351+P338
- target organs
- Respiratory system
- PPE
- 2 · Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
- Hazard Codes
- T,Xi
- Risk Statements
- 23 · 23/24/25-36/37/38-25
- Safety Statements
- 26 · 26-36/37/39-45-37/39-28A
- RIDADR
- 2811 · UN 2811 6.1/PG 2
- WGK Germany
- 3 · 3
- RTECS
- 5141000 · TJ5141000
- Hazard Note
- Irritant
- TSCA
- TSCA listed
- HazardClass
- 6.1 · 6.1
- PackingGroup
- III
- HS Code
- 29333999 · 29333999
- Storage Class
- 6.1 A · 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- Hazard Classifications
- 3 DermalAcute · Acute Tox. 3 DermalAcute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- Toxicity
- 50 orl-rat: · LD50 orl-rat: 200 mg/kg 85JCAE -,841,86
- REACH Registrations
- Active
- Limited Quantities
- 0.5 Kg · 0.5 Kg (solid)
- Excepted Quantities
- Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)
Safety & regulation
GHS classification
GHS Classification
Danger
H301 (98.3%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 60 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Status: Active Update: 15-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/20106
2-Amino-5-methylpyridine: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 3 (98.3%)
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- TJ5141000
- ridadr
- UN 2811 6.1/PG 2
- hs_code
- 29333999
- Toxicity
- LD50 orl-rat: 200 mg/kg 85JCAE -,841,86
- risk_code
- 23/24/25-36/37/38-25
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- hazard_code
- T,Xi
- hazard_note
- Irritant
- safety_code
- 26-36/37/39-45-37/39-28A
- hazard_class
- 6.1
- Storage Class
- 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
- packing_group
- III
- target organs
- Respiratory system
- Hazard statements
- H301+H311-H315-H319-H335
- Limited Quantities
- 0.5 Kg (solid)
- Excepted Quantities
- Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml)
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 3 DermalAcute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P280-P301+P310+P330-P302+P352+P312-P305+P351+P338
Chemistry & industry
Uses & manufacturing
General Manufacturing Information2-Pyridinamine, 5-methyl-: ACTIVE
Applications
Uses2-Amino-5-methylpyridine is used as an intermediate in the pharmaceutical industry for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of Fluazuron, which is a pesticide, and for commercial purposes.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
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Related reactions
840 records
Compound notes
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