2,5-Dihydrofuran

HCID 15570

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Basic information

CAS: 1708-29-8
Standard SMILES: C1=CCOC1
InChIKey: ARGCQEVBJHPOGB-UHFFFAOYSA-N
Molecular formula: C4H6O
Average molar mass: 70.09 g/mol
Monoisotopic mass: 70.04186481

Overview

structure in first source

Names & identifiers

Preferred name: 2,5-Dihydrofuran
IUPAC: 2,5-dihydrofuran
English name: 2,5-Dihydrofuran
Molecular formula: C4H6O
Molecular weight: 70.09

Names & synonyms

2,5-DIHYDROFURAN1708-29-8Furan, 2,5-dihydro-HD0TIE091TNSC-60532DTXSID5051785RefChem:82859DTXCID8030340216-957-43-Oxolene1-Oxa-3-cyclopenteneMFCD00003219

Show more names

Dihydrofuran2,5-DHF2,5-Dihyrofuran2,5-dihydro-fura2,5 DIHYDROFURANE1,4-EPOXY-2-BUTENEOXA-3-CYCLOPENTENE

2,5-Dihydrofuran; NSC 605322,5-Dihydro-furanEINECS 216-957-4NSC 60532Furan,5-dihydro-NSC60532UNII-HD0TIE091TEC 216-957-4

Database identifiers

CAS: 1708-29-8
PubChem CID: 15570
DTXSID: DTXSID5051785
ChEMBL: CHEMBL117135
UNII: HD0TIE091T
EC Number: 216-957-4
Nikkaji: J41.176K

Properties

Computed structural properties

XLogP: 0.5
Topological polar surface area: 9.2 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 5
Formal charge: 0
Complexity: 41.6

Experimental & physicochemical properties

Chemical ClassesOther Classes -> Ethers, Other

SpringerMaterials PropertiesCoriolis coupling

Physical DescriptionYellow liquid; [Aldrich MSDS]

Physicochemical properties

Boiling point: 66 · 66-67 °C (lit.)
Density: 0.927 g/mL · 0.927 g/mL at 25 °C (lit.)
vapor pressure: 16.265 kPa · 16.265kPa at 20℃
refractive index: 1.431 · 1.431
Flash point: 2 °F · 2°F
storage temp.: 30 °C · Store below +30°C.
solubility: soluble in Chloroform, Ethyl Acetate
form: Liquid
color: Colorless to yellow
Odor Threshold: 0.093 ppm · 0.093ppm
BRN: 103174 · 103174
InChI: 1S/C4H6O/c1-2-4-5-3-1/h1-2H,3-4H2
InChIKey: ARGCQEVBJHPOGB-UHFFFAOYSA-N
SMILES: C1OCC=C1
LogP: 0.46 · 0.46
CAS DataBase Reference: 1708 · 1708-29-8(CAS DataBase Reference)
EWG's Food Scores: 1 · 1
FDA UNII: 0 TIE091T · HD0TIE091T
NIST Chemistry Reference: 2 · Furan, 2,5-dihydro-(1708-29-8)
EPA Substance Registry System: 2 · Furan, 2,5-dihydro- (1708-29-8)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 2 · GHS02
Signal word: Danger
Hazard statements: 225 · H225
Precautionary statements: 210 · P210
PPE: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes: F
Risk Statements: 11 · 11-19-2017/11/19
Safety Statements: 9 · 9-16-33
RIDADR: 1993 · 1993
WGK Germany: 3 · 3
RTECS: 660000 · LU0660000
TSCA: TSCA listed
HazardClass: 3.1 · 3.1
PackingGroup: II
HS Code: 29321900 · 29321900
Storage Class: 3 · 3 - Flammable liquids
Hazard Classifications: 2 · Flam. Liq. 2
REACH Registrations: Inactive

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 149 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

Chemical: Furan, 2,5-dihydro-

Status: Cease Manufacture Update: 08-01-2015 https://echa.europa.eu/registration-dossier/-/registered-dossier/11932

2,5-Dihydrofuran: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1 item

Tremors, reduced muscle tone, abnormal gait, histopathological changes in the nasal passages, and significantly reduced body weight observed in 4-week inhalation study of rats at 1,250 ppm; [EPA TSCATS] May cause irritation; [Aldrich MSDS] See 2,3-Dihydrofuran.

Hazard Classes and CategoriesFlam. Liq. 2 (100%)

Toxicology

Adverse EffectsNeurotoxin - Acute solvent syndrome

Safety data

PPE: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
wgk: 3
tsca: TSCA listed
rtecs: LU0660000
ridadr: 1993
hs_code: 29321900
risk_code: 11-19-2017/11/19
Signal word: Danger
Symbol(GHS): GHS02
hazard_code: F
safety_code: 9-16-33
hazard_class: 3.1
Storage Class: 3 - Flammable liquids
packing_group: II
Hazard statements: H225
REACH Registrations: Inactive
Hazard Classifications: Flam. Liq. 2
Precautionary statements: P210

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationFuran, 2,5-dihydro-: ACTIVE

Applications · 2 items

Uses2,5-Dihydrofuran is used in the synthesis of Sch 38516 aglycon (fluvirucin B1) an influenza A antibiotic.

General DescriptionAdsorption and thermal chemistry of 2,5-dihydrofuran on Pd (111) has been studied by high-resolution electron energy loss spectroscopy and temperature-programmed desorption. Free jet millimetre wave spectrum of the 2,5-dihydrofuran-argon molecular complex has been investigated in the frequency range 60-78GHz.