Tenocyclidine hydrochloride (1:1)
GK 0 · CL-421 · Thienylcyclidine · Thienylphencyclidine · 1-[1-(2-Thienyl)cyclohexyl]piperidine Hydrochloride · 1-(1-thiophen-2-ylcyclohexyl)piperidine:hydrochloride
Identifiers & Physical Properties
| CAS No. | 1867-65-8 |
|---|---|
| Molecular formula | C15H24ClNS |
| Average molar mass | 285.884 g/mol |
| Monoisotopic mass | 285.13179845 g/mol |
| SMILES | Cl.c1csc(C2(N3CCCCC3)CCCCC2)c1 |
| InChIKey | IIPLEZRBGQCZMF-UHFFFAOYSA-N |
| PubChem CID | 16640802 |
| EC No. | 631-590-3 |
| DTXSID | DTXSID40904770 |
Chemical & Physical Properties
| Melting point | 233-236 °C |
|---|---|
| Solubility | DMF: 5 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/mlMethanol: 1 mg/ml |
| Physical state | A crystalline solid |
| FDA UNII | 425WW340S2 |
| GHS pictogram | GHS07,GHS05 |
| Signal word | Danger |
| GHS hazard statements | H318-H335-H315 |
| GHS precautionary statements | P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362 |
Safety & Regulations
| Signal word | Danger |
|---|---|
| GHS pictogram | GHS07,GHS05 |
| GHS hazard statements | H318-H335-H315 |
| GHS precautionary statements | P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362 |
Applications & Uses
Description
Tenocyclidine (TCP), known more formally as N-[1-(2-thienyl)cyclohexyl] piperidine, is an analog of phencyclidine (PCP) in which the phenyl substituent is replaced with a thiophene group. TCP is a potent antagonist of the NMDA receptor-gated ion channel (Kd = 9 nM). TCP blocks NMDA-activated excitatory postsynaptic potential in brain more potently than PCP. PCP and many analogs, including TCP, block the uptake and enhance the release of dopamine both in vitro and in vivo. TCP is regulated as a Schedule I compound in the United States. This product is intended for forensic and research applications.
Uses
An analog of the hallucinogen Phencyclidine (P295500).