Enprofylline

HCID 1676CAS 41078-02-8

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Basic information

Standard SMILES
CCCn1c(=O)[nH]c(=O)c2[nH]cnc21
InChIKey
SIQPXVQCUCHWDI-UHFFFAOYSA-N
Molecular formula
C8H10N4O2
Average molar mass
194.194 g/mol
Monoisotopic mass
194.08037556

Names & identifiers

Preferred name
Enprofylline
IUPAC
3-Propyl-3,7-dihydro-1H-purine-2,6-dione
English name
ENPROFYLLINE
Molecular formula
C8H10N4O2
Molecular weight
194.19

Names & synonyms

d-4028nilyphEnprofilinaENPROFYLLINEENPROPHYLLINEEnprofyllilieEnprofyllinum3-PROPYLXANTHINE3-Propylxanthfine3-N-PROPYLXANTHINE

Database identifiers

CAS
41078-02-8
PubChem CID
1676
DTXSID
DTXSID9045186
ChEMBL
CHEMBL279898
ChEBI
CHEBI:126237
UNII
DT7DT5E518
EC Number
255-201-8
Nikkaji
J16.542E

Properties

Physicochemical properties

Melting point
287 · 287-289 °C
Density
1.38 g/cm3 · 1.38 g/cm3
storage temp.
2 · 2-8°C
solubility
DMSO: soluble
form
solid
pka
10.26 · 10.26±0.20(Predicted)

Safety & regulation

Safety data

wgk
3
rtecs
UO8439700
risk_code
20/21/22
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xn

Chemistry & industry

Applications · 3 items

Description3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (Kis = 44, 32, and 6.3 μM for A1, A2A, and A2B, respectively) and cAMP phosphodiesterase (Ki = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.

UsesBronchodilator.

UsesEnprofylline is a xanthine lacking adenosine receptor antagonism.

Upstream & downstream products

Upstream raw materials

Suppliers27 total

北京华美互利生物化工010-56205725 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Additional notes · 1 item

DefinitionChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n uropathy.

Related reactions

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