Enprofylline → HCID 14014540, compound

HRID 985943

Reaction equation

HRID 985943 reaction equation
[CH2:1]([N:4]1[C:12]2[N:11]=[CH:10][NH:9][C:8]=2[C:7](=O)[NH:6][C:5]1=[O:14])[CH2:2][CH3:3].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:16]>N1C=CC=CC=1>[CH2:1]([N:4]1[C:12]2[N:11]=[CH:10][NH:9][C:8]=2[C:7](=[S:16])[NH:6][C:5]1=[O:14])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 1676EnprofyllineHCID 14817Phosphorus sulfide (P2S5)

Product 1

HCID 14014540HCID 14014540, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Procedure

A suspension of 9.32 g. (48 mM.) of 3-propylxanthine in 80 ml. of pyridine, was treated with 17.33 g. (78 mM.) of phosphorus pentasulfide in 80 ml. of pyridine, and worked up analogously to Example I. 8.9 g. of 3-propyl-6-thioxanthine was obtained. Recrystallization from methanol-acetone gave 7.4 g. (59% yield) of needles with a melting point of 249°-250° C.

Workup

  1. additionA suspension of 9.32 g

Sources & evidence

ORD record
ord-d2a3177f855d42d6a0dcc040f2a3c249
Source dataset
uspto-grants-1987_12
Patent number
US04710503

Linked notes

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