2,6-Dichloropyridine

HCID 16989
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Basic information

CAS
2402-78-0
Standard SMILES
Clc1cccc(Cl)n1
InChIKey
FILKGCRCWDMBKA-UHFFFAOYSA-N
Molecular formula
C5H3Cl2N
Average molar mass
147.99 g/mol
Monoisotopic mass
146.9642545

Names & identifiers

Preferred name
2,6-Dichloropyridine
IUPAC
2,6-dichloropyridine
English name
2,6-Dichloropyridine
Molecular formula
C5H3Cl2N
Molecular weight
147.99

Names & synonyms

2,6-DICHLOROPYRIDINE2402-78-0Pyridine, 2,6-dichloro-DTXSID2051895WM26PC2SBWNSC-76606DTXCID0030457RefChem:83196219-282-3MFCD000062442,6-Dichloro-pyridine2,6-Dichloropyridine, 98%
Show more names
26DCLPYAURORA KA-64952,6-DichLoropyridineAKOS BBS-000043142,6-Dichloropyridinr2,6-dichloro-pyridinTrazodone Impurity 30
CCRIS 1727EINECS 219-282-3NSC 76606BRN 0108664NSC766062,6-dichlorpyridine2.6-dichloropyridineUNII-WM26PC2SBW

Database identifiers

CAS
2402-78-0
PubChem CID
16989
DTXSID
DTXSID2051895
ChEMBL
CHEMBL3561947
UNII
WM26PC2SBW
EC Number
219-282-3
Nikkaji
J51.304K

Properties

Computed structural properties

XLogP
2.2
Topological polar surface area
12.9 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
1
Rotatable bonds
0
Heavy atoms
8

Experimental & physicochemical properties

Physical Description · 2 items

Wet Solid

White crystalline solid; [Alfa Aesar MSDS]

Physicochemical properties

Melting point
83 · 83-86 °C (lit.)
Boiling point
211 °C · 211 °C
Density
1.5159 · 1.5159 (rough estimate)
refractive index
1.55 · 1.5500 (estimate)
Flash point
110 °C · 110°C
storage temp.
2 · Inert atmosphere,2-8°C

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H301 (96.6%): Toxic if swallowed [Danger Acute toxicity, oral]；H315 (15.5%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (15.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (12.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 58 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 2 items

Pyridine, 2,6-dichloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Pyridine, 2,6-dichloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Pyridine, 2,6-dichloro-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses somnolence and fatty liver degeneration in intraperitoneal lethal-dose studies of mice; [RTECS] An irritant; Toxic by ingestion; [Alfa Aesar MSDS] See Pyridine.
Hazard Classes and CategoriesAcute Tox. 3 (96.6%)；Skin Irrit. 2 (15.5%)；Eye Irrit. 2A (15.5%)；STOT SE 3 (12.1%)

Toxicology

Adverse EffectsNeurotoxin - Other CNS neurotoxin；Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Regulatory information

Regulatory Information · 2 items

Pyridine, 2,6-dichloro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Pyridine, 2,6-dichloro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Pyridine, 2,6-dichloro-: Does not have an individual approval but may be used under an appropriate group standard

Safety data

PPE
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
wgk
3
tsca
TSCA listed
rtecs
US8400000
ridadr
UN 2811 6.1/PG 2
hs_code
29333999

Chemistry & industry

Uses & manufacturing

U.S. Production2023: 53,953 lb；2022: 186,928 lb；2021: 226,252 lb；2020: 232,841 lb
Industry UsesIntermediate
General Manufacturing Information · 2 items

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing

Pyridine, 2,6-dichloro-: ACTIVE

Applications · 2 items

Description2,6-Dichloropyridine is an important intermediate that is widely used in the medicine and pesticide research field. It could be used as a starting material to synthesize the pirozadil (Pirozadil) which can be used for reducing blood-fat, and antiplatelet condensation. 2,6-dichloropyridine also can be used to synthetic musk pyridine with alternative natural musk. 2,3,5, 6-TCP produced by further chlorination of 2, 6-dichloropyridine is an important raw material for chlorpyrifos, which is widely used in the world with high efficiency, broad spectrum, and low residue.

Uses2,6-Dichloropyridine is used in the preparation of triazolo and imidazo potassium channel antagonists as antiarrythmic agents.

Upstream & downstream products

Upstream raw materials

Suppliers100 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
山东艾利特生物科技有限公司0539-18853986-090 13053958157 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

Related reactions

156 records
New reaction record

Compound notes

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