2,6-Dichloropyridine → 2-Chloro-6-(3-thienylmethyloxy)pyridine
Reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([CH2:6][OH:7])=[CH:2]1.[H-].[Na+].[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13](Cl)[N:12]=1>O1CCCC1>[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:7][CH2:6][C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)[N:12]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution containing 3-thiophenemethanol (1.17 g, 0.010×1.0 mol) and sodium hydride (0.39 g, (ca.60% in mineral oil), 0.010×1.0 mol) in tetrahydrofuran, 2,6-dichloropyridine (1.5 g, 0.010 mol) was added and the resultant solution was refluxed for about 2 hours.
Workup
- additionwas added
Sources & evidence
- ORD record
- ord-6773e5477f9c431ab909d7a6d265626e
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05624942
Reaction notes
Loading…