2-Chloro-p-phenylenediamine sulfate

Danger

H301 (12.2%): Toxic if swallowed [Danger Acute toxicity, oral]；H311 (12.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]；H312 (85.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H315 (87.8%): Causes skin irritation [Warning Skin corrosion/irritation]；H317 (14.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H331 (12.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]；H332 (85.7%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H335 (85.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Chemical: 1,4-Benzenediamine, 2-chloro-, sulfate

Status: Cease Manufacture Update: 04-01-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21658

1,4-Benzenediamine, 2-chloro-, sulfate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Final Report on the safety assessment of 2-chloro-p-phenylenediamine and 2-chloro-p-phenylenediamine sulfate. J Am Coll Toxicol 11(4) 521-30 (1992).

EVIDENCE IS GIVEN SUPPORTING TESTING OF THE CLASS OF COMPOUNDS PHENYLENEDIAMINES FOR THEIR TOXIC EFFECTS ON HUMAN HEALTH AND THE ENVIRONMENT. THE RESULTS OF TOXICITY TESTING OF 22 COMPOUNDS ARE TABULATED AS ARE THE EFFECTS FOR WHICH TESTING IS BEING CONSIDERED FOR 13 COMPOUNDS, AND THE USES OR POTENTIAL USES OF 47 PHENYLENEDIAMINES.[UNITED STATES EPA; PHENYLENEDIAMINES; RESPONSE TO INTERAGENCY TESTING COMMITTEE; FED REGIST 47(5) 973 (1982)]

An acidic salt of an amine. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Acute Tox. 3 (12.2%)；Acute Tox. 3 (12.2%)；Acute Tox. 4 (85.7%)；Skin Irrit. 2 (87.8%)；Skin Sens. 1 (14.3%)；Eye Irrit. 2 (100%)；Acute Tox. 3 (12.2%)；Acute Tox. 4 (85.7%)；STOT SE 3 (85.7%)

Acute Tox. 3 (21.4%)；Acute Tox. 4 (25%)；Acute Tox. 3 (21.4%)；Acute Tox. 4 (10.7%)；Skin Irrit. 2 (35.7%)；Skin Sens. 1 (82.1%)；Eye Irrit. 2 (100%)；Acute Tox. 3 (21.4%)；Acute Tox. 4 (14.3%)；STOT SE 3 (35.7%)；Aquatic Acute 1 (21.4%)；Aquatic Chronic 1 (21.4%)

Acute toxicity (ingestion) - category 4；Skin sensitisation - category 1B

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should store this material under ambient temperatures. (NTP, 1992)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.；SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.；Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. /2-Chloro-p-phenylenediamine sulfate (1:1)/ [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=61702-44-1]

2-Chloro-p-phenylenediamine sulfate

TR-113: Bioassay of 2-Chloro-p-phenylenediamine Sulfate for Possible Carcinogenicity (CASRN 61702-44-1) (1978 )

04/26/78

No Evidence

No Evidence

No Evidence

A BIOASSAY FOR POSSIBLE CARCINOGENICITY OF 2-CHLORO-P-PHENYLENEDIAMINE SULFATE WAS CONDUCTED USING RATS AND MICE. THE COMPOUND WAS ADMINISTERED IN THE FEED, AT EITHER OF 2 CONCENTRATIONS, TO GROUPS OF MALE AND FEMALE ANIMALS OF EACH SPECIES. THE DIETARY CONCENTRATIONS USED WERE 0.3 AND 0.15% FOR THE HIGH AND LOW DOSE RATS, RESPECTIVELY, AND 0.6 AND 0.3% FOR THE HIGH AND LOW DOSE MICE, RESPECTIVELY. COMPOUND ADMINISTRATION WAS FOR 105-107 WEEKS IN RATS, 87 WEEKS IN HIGH DOSE MICE, AND 104-105 WEEKS IN LOW DOSE MICE. THERE WAS INSUFFICIENT EVIDENCE THAT DIETARY ADMINISTRATION WAS CARCINOGENIC TO RATS OR MICE.

Chemical: 1,4-Benzenediamine, 2-chloro-, sulfate

Status: Cease Manufacture Update: 04-01-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21658

1,4-Benzenediamine, 2-chloro-, sulfate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.