Sodium Iodate

Cosmetic ingredients (Sodium Iodate) -> CIR (Cosmetic Ingredient Review)

Preservative

4.28

4.277 @ 17.5°C

White, crystal powder

White rhombic crystals

Solubility in water: 9 g/100 cc @ 20 °C; 34 g/100 cc @ 100 °C; soluble in acetic acid; insol in alcohol

9.0 g/100g H2O at 25 °C

Danger

H272 (91.7%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P210, P220, P233, P260, P261, P264, P270, P271, P272, P280, P284, P301+P317, P302+P352, P304+P340, P321, P330, P333+P317, P342+P316, P362+P364, P370+P378, P403, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 72 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H272: May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

Chemical: Iodic acid (HIO3), sodium salt

Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/25574

Sodium iodate: Does not have an individual approval but may be used under an appropriate group standard

An oxidizing agent; Fire hazard near organic substances; [Hawley] Toxic to retina after injection in animal studies; Iodate salts cause liver injury, hemoglobinuria, and renal failure in high-dose animal studies; Have similar hemolytic potential to chlorate and bromate salts; Chronic dosing can produce iodism with rhinitis, skin rashes, weight loss, palpitations, tremors, and occasionally symptoms of Graves disease; [HSDB] Causes convulsions, retinal changes, and proteinuria in intravenous, lethal-dose animal studies; [RTECS] An oxidizing agent; May cause fire on contact with combustible material; An irritant; May cause skin and respiratory sensitization after prolonged contact; Effects in high-dose animal studies include convulsions; [MSDSonline]

NATRUM IODATUM

Osmotic Activity [MoA]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Increased Large Intestinal Motility [PE]; Osmotic Laxative [EPC]

WHEN IODATE (131)I HAS BEEN GIVEN INTRAVENOUSLY, LABELED IODINE HAS BEEN FOUND TO PASS RAPIDLY INTO AQUEOUS & VITREOUS HUMORS IN RABBITS. THAT REMAINING IN BLOOD PERSISTS FOR MANY HOURS & IS GRADUALLY REDUCED BY THE LIVER TO IODIDE. /IODATE/

WITHIN FEW MIN AFTER SINGLE IV DOSE THERE WAS MARKED INCR IN RATE OF PENETRATION OF SODIUM, IODINE & THIOUREA INTO VITREOUS BODY OF RABBIT, MAX EFFECT REACHED WITHIN 30-60 MIN. PATTERN OF ALTERED PERMEABILITY OF BLOOD-VITREAL BARRIER CONFIRMED IDEA OF EXCLUSIVE ATTACK ON CILIARY BODY.

EXPT RETINAL DEGENERATION INDUCED IN RABBITS BY DAILY INJECTIONS OF 30 MG/KG. IN 2-24 HR INTENSE FLUORESCEIN COLORATION APPEARED IN OUTER PART OF RETINA. IN 1-3 WK FLUORESCEIN PASSAGE INTO RETINA GRADUALLY DECR ALTHOUGH THE ALMOST VISUAL CELLS HAD DISAPPEARED.

ACCUM OF IODATE IN EYE TISSUES & FLUIDS AS POSSIBLE EXPLANATION OF RETINOTOXIC EFFECT OF IODATE WAS STUDIED BY IV INJECTION OF NAIO3 (30 MG/KG). EFFECT OF IODATE IS NOT DUE TO ACCUM OF IO3 IN EYE TISSUE, BUT TO DAMAGE TO BIOCHEM MECHANISMS INVOLVED IN REDN TO I-.

CIR ingredient: Sodium Iodate

Used as trace mineral additive in animal feeds and table salt; Also used as a disinfectant and antiseptic; [HSDB]

Using Disinfectants or Biocides [Category: Clean]

Trace mineral added to animal feeds, disinfectants, antiseptic

ADDITIVE IN TABLE SALT

Antiseptic for mucous membranes

Interaction of sodium chlorate & iodine in presence of nitric acid.

Prepared by oxidation of iodine to iodic acid followed by neutralization with an oxide or hydroxide; or by electrolytic oxidation of an iodide solution.