Piperazine → HCID 46186740, compound

HRID 547984

Reaction equation

HRID 547984 reaction equation
[CH3:1][O:2][C:3](=[O:19])[C:4]([C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1)([CH:9]([CH3:11])[CH3:10])[CH2:5][CH2:6][CH2:7]Br.[C:20]1([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.N1CCNCC1.CCN(CC)CC.I([O-])(=O)=O.[Na+]>C(#N)C>[CH3:1][O:2][C:3](=[O:19])[C:4]([C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=1)([CH:9]([CH3:11])[CH3:10])[CH2:5][CH2:6][CH2:7][N:29]1[CH2:30][CH2:31][N:26]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:27][CH2:28]1

Participants

7

Reactant 5

HCID 4837PiperazineHCID 70961-PhenylpiperazineHCID 8471TriethylamineHCID 23675764Sodium IodateHCID 46855860HCID 46855860, compound

Product 1

HCID 46186740HCID 46186740, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

After the 5-bromo-2-(4-bromophenyl)-2-isopropylpentanoic acid methyl ester (200 mg, 1 eq) was dissolved in acetonitrile, 4-phenylpiperazine (70 mg, 1 eq) as a piperazine derivative, Et3N (0.06 ml, 1.2 eq), and sodium iodate were added into the solution and heated and refluxed for 3 hours. When the reaction was completed, the precipitate was filtrated and the mixture was vacuum distilled and extracted with ethyl acetate and water. After the organic layer was washed with 1N HCl and saturated NaHCO3, the target compound 2-(4-bromophenyl)-2-isopropyl-5-(4-phenylpiperazine-1-yl)pentanoic acid methyl ester was obtained by drying the mixture with anhydrous sodium sulfate and removing the solvent at low pressures (69 mg, 42%).

Workup

  1. temperatureheated
  2. temperaturerefluxed for 3 hours
  3. filtrationthe precipitate was filtrated
  4. distillationdistilled
  5. extractionextracted with ethyl acetate and water
  6. washAfter the organic layer was washed with 1N HCl and saturated NaHCO3

Sources & evidence

ORD record
ord-5be30e553d664163ac3b72e36c175460
Source dataset
uspto-grants-2011_05
Patent number
US07939672B2

Linked notes

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