Tricalcium Phosphate

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Residues of calcium phosphate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Residues of calcium phosphate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. /Calcium phosphate/

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Calcium Phosphate...

Safe for use in cosmetics, with qualifications

The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Tricalcium Phosphate...

Safe for use in cosmetics, with qualifications

IDENTIFICATION AND USE: White amorphous, or crystaline powder. It is odorless and tasteless. It is practically insoluble in alcohol, and acetic acid, and soluble in dilute hydrochloric acid, and nitric acid. Slightly soluble in water. It is used in the manufacture of fertilizers, phosphate compounds, manufacture of milk glass, polishing and dental powders, porcelains, pottery, enameling; clarifying sugar syrups; in animal feeds; as noncaking agent; in textile industry. It is used as a stabilizer in plastics; in meat tenderizers; in food as a buffer and used in medical applications as a calcium replenisher. It veterinary medicine it is used as a dietary supplement and an antacid. It is used in the manufacture of luminescent materials. HUMAN EXPOSURE AND TOXICITY: Tricalcium phosphate is not irritating and toxic doses by ingestion would have to be more than 2 g/kg. Skin sensitization is unusual. Aspiration or inhalation could cause chemical pneumonitis. Implantation of material will cause foreign body reaction. Tricalcium phosphate is contraindicated in treatment of hypocalcemia with hyperphosphatemia which may occur in hypoparathyroidism and renal failure. ANIMAL STUDIES: Tricalcium phosphate exhibited no teratogenic effect in developing chicken embryos.

Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.

USUALLY OBTAINED FROM ANIMAL BONES WHICH CONTAIN ABOUT 80% OF TRIBASIC CALCIUM PHOSPHATE. /TRIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY/

... NOT IRRITATING & TOXIC DOSES BY INGESTION WOULD HAVE TO BE IN EXCESS OF 2 G/KG. ... SKIN SENSITIZATION IS UNUSUAL. ASPIRATION OR INHALATION ... COULD CAUSE CHEM PNEUMONITIS. IMPLANTATION ... WILL CAUSE FOREIGN BODY REACTION. /CALCIUM PHOSPHATE/

48.6

PPRTV Archive

8

PPRTV Current

FAO/WHO EXPERT COMMITTEE ON FOOD ADDITIVES...RECOMMENDED.../LEVELS/ FOR TOTAL DIETARY PHOSPHORUS...UNCONDITIONAL ACCEPTANCE LEVEL /OF LESS THAN 30 MG/KG BODY WT/ IS CONSIDERED SAFE IN ANY TYPE OF DIET...CONDITIONAL ACCEPTANCE LEVEL /OF 30-70 MG/KG BODY WT/ IS ACCEPTABLE ONLY WHEN DIETARY CALCIUM LEVEL IS HIGH /PHOSPHATES/

Tricalcium phosphate

8 mg/kg-day

PDF Document

Inadequate information to assess carcinogenic potential

2021

Substances classified as stabilizers, when migrating from food-packaging material shall incl ... calcium phosphate.

Calcium phosphate (mono-, di-, and tribasic) used as a multiple purpose GRAS food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/

Calcium phosphate (mono-, di-, tribasic) used as a dietary supplement in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/

Calcium phosphate (mono-, di-, and tribasic) used as a nutrient in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/

For more FDA Requirements (Complete) data for TRICALCIUM PHOSPHATE (6 total), please visit the HSDB record page.

Residues of calcium phosphate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

CIR ingredient: Calcium Phosphate

CIR ingredient: Tricalcium Phosphate

Found in the minerals oxydapatit, voelicherite, and whitlockite; [Merck Index] Used to make fertilizers, phosphoric acid, phosphorus compounds, milk-glass, polishing and dental powders, porcelains, pottery, and luminescent materials; Also used in enamels, white pigments for ceramics, meat tenderizers, food buffers and flow conditioners, and as a non-caking agent, a mordant in dyeing, a stabilizer for plastics, a clarifying agent for sugar syrups, a polishing agent, a calcium supplement, and a veterinary antacid; [HSDB]

Textiles (Printing, Dyeing, or Finishing) [Category: Industry]

Ceramics making [Category: Hobbies]

Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Used in fertilizers, food additives, and animal feeds; [IUCLID] Also used in glass manufacture; [EPA OHM/TADS]

(1972) 1.35X10+10 GRAMS (CRUDE)

(1976) 1.36X10+10 G (CRUDE)

2023: 400,000 - <550,000 lb

2023: 381,191 lb

(1972) 4.22X10+11 GRAMS (CRUDE)

(1976) 2.86X10+11 GRAMS (CRUDE)

ESSENTIALLY 100% OF TRICALCIUM PHOSPHATE IS USED IN THE CRUDE FORM (DEFLUORINATED PHOSPHATE ROCK) AS A MINERAL SUPPLEMENT IN LIVESTOCK & POULTRY FEEDS; SMALL AMOUNTS OF REFINED TRICALCIUM PHOSPHATE ARE USED AS FOOD ADDITIVES TO CONTROL THE PH IN DOUGHS & LARD, & AS A YEAST NUTRIENT IN FLOUR (1972)

Corrosion inhibitor

Intermediate

Lubricating agent

Filler

HIGH TEMPERATURE REACTION OF PHOSPHATE ROCK, SILICA, WET-PROCESS PHOSPHORIC ACID, & SODA ASH (FEED-GRADE); REACTION OF FURNACE PHOSPHORIC ACID & CALCIUM OXIDE OR CALCIUM NITRATE (FOOD-GRADE)

... /ANIMAL/ BONES ARE CALCINED UNTIL WHITE, THEN GROUND & DIGESTED WITH HYDROCHLORIC ACID /OR SULFURIC ACID/... AFTER FILTRATION, SOLN IS TREATED EITHER WITH AMMONIA OR MORE GENERALLY WITH CALCIUM HYDROXIDE WHEREBY CALCIUM PHOSPHATE IS PPT. /TRIBASIC CALCIUM PHOSPHATE NF/

By interaction of solutions of calcium chloride & sodium triphosphate with excess of ammonia.

Commercial preparation from phosphate rock.

In production, hydroxyapitite, Ca5(PO4)3OH. is formed by the complete neutralization of phosphoric acid with slaked lime and subsequent filtration, drying, and grinding. The Ca/P ratio depends on the process conditions. Pure Ca3(PO4)2, can be obtained from hydroxyapitite by calcination above 900 °C.

Grade: it is about 96% pure, usually containing an excess of calcium oxide.

Grades: granular; technical; chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity; National Formulary; pure precipitated; Food Chemicals Codex.

Food additives

Fragrance Ingredients

Food Additives -> ACIDITY_REGULATOR; ANTICAKING_AGENT -> JECFA Functional Classes

Food Additives -> ACIDITY_REGULATOR; ANTICAKING_AGENT -> JECFA Functional Classes

Food Additives -> ACIDITY_REGULATOR; ANTICAKING_AGENT -> JECFA Functional Classes

Cosmetics -> Opacifying; Bulking; Anticaking; Viscosity controlling; Oral care; Buffering; Abrasive; Antiplaque

Paint and Coating Manufacturing

Paper Manufacturing

Phosphoric acid, calcium salt (2:3): ACTIVE

Phosphoric acid, calcium salt (1:?): ACTIVE

... VARIABLE MIXT OF CALCIUM PHOSPHATES ... APPROX COMPOSITION 10CAO.3P2O5.H2O (1004.64). IT CONTAINS AN AMT OF PHOSPHATE (PO4) EQUIVALENT TO NOT LESS THAN 90.0% OF TRIBASIC CALCIUM PHOSPHATE ... CALCULATED ON THE IGNITED BASIS. /TRIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY/

... CAN INACTIVATE METALLIC IONS, WHICH ARE CAPABLE OF INTERFERING WITH NECESSARY FOOD-PROCESSING REACTIONS ... /INACTIVATION IS/ EITHER BY PPTN & REMOVING THEM FROM INTERFERENCE WITH DESIRED FOOD-PROCESSING REACTIONS OR BY COMPLEXING & MAINTAINING THEM IN SOL, BOUND STATE. /PHOSPHATES/