Diammonium hydrogen phosphate

HCID 24540CAS 7722-76-1

Basic information

Standard SMILES
O=P([O-])([O-])O.[NH4+].[NH4+]
InChIKey
MNNHAPBLZZVQHP-UHFFFAOYSA-N
Molecular formula
(NH4)2HPO4
Average molar mass
132.06 g/mol
Monoisotopic mass
132.0299934

Overview

Ammonium phosphate is a white solid with a weak odor of ammonia. Sinks and mixes with water. (USCG, 1999)

Names & identifiers

Preferred name
Diammonium hydrogen phosphate
IUPAC
diazanium;hydrogen phosphate
English name
Ammonium dihydrogen phosphate
Molecular formula
H6NO4P
Molecular weight
115.03

Names & synonyms

7783-28-0Diammonium hydrogen phosphateDIAMMONIUM PHOSPHATEAmmonium phosphate dibasicPhosphoric acid, diammonium saltAkoustan APelorCoaltrol LPA 445Diammonium orthophosphateDiammonium acid phosphateK2 (phosphate)Diammonium hydrogen orthophosphate
Show more names
MAPMONOAMMONIUM PHOSPHATEAMMONIUM PHOSPHATE12-61-00AMMONIUM DIHYDROGEN ORTHOPHOSPHATEAmmonium dihydrogenAMMONIUM BIPHOSPHATEmonoammoniumacidphosphateAMMONIUM PHOSPHATE, MONOBASICPHOSPHORIC ACID MONOAMMONIUM SALT
Secondary ammonium phosphateHydrogen diammonium phosphateAmmonium orthophosphate dibasicDiammonium monohydrogen phosphateAmmonium hydrogen phosphateAmmonium phosphate, secondaryPyrozyl war10LGE70FSU

Database identifiers

CAS
7722-76-1、7783-28-0
PubChem CID
24540
DTXSID
DTXSID6029705
ChEMBL
CHEMBL2105954
ChEBI
CHEBI:63051
UNII
10LGE70FSU
EC Number
231-987-8

Properties

Computed structural properties

Topological polar surface area
85.4 Ų
Hydrogen bond donors
3
Hydrogen bond acceptors
4
Rotatable bonds
0
Heavy atoms
7

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Ammonium Compounds
Cosmetics · 3 items

Cosmetic ingredients (Ammonium Phosphate) -> CIR (Cosmetic Ingredient Review)

Cosmetic ingredients (Diammonium Phosphate) -> CIR (Cosmetic Ingredient Review)

Oral care; Buffering

pHpH about 8
Pesticides · 2 items

Attractants

Active substance -> EU Pesticides database: Approved

Odor · 2 items

Odorless

Weak ammonia odor

TasteSaline, cooling taste

Physicochemical properties

Melting point
190 °C · 190 °C (dec.) (lit.)
Boiling point
87.4 °C · 87.4 °C
Density
1.02 g/mL · 1.02 g/mL at 20 °C
bulk density
800 · 800-1100kg/m3
vapor pressure
0.066 hPa · 0.066 hPa (125 °C)
RTECS
6587000 · TC6587000

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 80.1% (514 of 642) of all reports.

Warning

H315 (18.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 642 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 5 items

Chemical: Phosphoric acid, diammonium salt

Phosphoric acid, ammonium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, ammonium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

2002/2076, Reg. (EU) 2016/548, Reg. (EU) No 540/2011

Status: Active Update: 21-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15555

Ammonium monohydrogen orthophosphate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Phosphoric acid, diammonium salt: Human health tier I assessment
Fire Hazards · 2 items

Special Hazards of Combustion Products: Toxic and irritating fumes of ammonia and oxides of nitrogen may form in fires. (USCG, 1999)

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

Fire PotentialNoncombustible.
Health Hazards · 1 item

Inhalation of monoammonium form causes irritation of mucous membranes; with diammonium form, ammonia vapors in closed area can cause pulmonary edema and asphyxia. Contact with solid or with ammonia gas causes irritation of eyes and skin. (USCG, 1999)

Hazards SummaryAn eye irritant; [ICSC] Ammonia vapors may accumulate in a confined space and cause pulmonary edema; [CAMEO] Caused contact dermatitis in surgical personnel wearing gowns containing this flame retardant; [Kanerva, p. 1778]

Safety & protection

Fire FightingIn case of fire in the surroundings, use appropriate extinguishing media.
First Aid Measures · 4 items

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention .

First AidINHALATION: if exposed to ammonia fumes from diammonium phosphate, give artificial respiration and oxygen if needed; enforce rest.
Safe StorageSeparated from strong oxidants, strong bases and strong acids. Keep in a well-ventilated room.
Firefighting HazardsPoisonous gases including ammonia, phosphorus oxides, and nitrogen oxides are produced in fire.
Fire Fighting Procedures · 1 item

Use extinguishing agents suitable for surrounding fire. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any sign of deforming), withdraw immediately to a secure position.

Toxicology

Interactions · 1 item

This paper summarizes data on the factors involved in addiction and dependence to cigarettes. Nicotine has been intensively studied by the tobacco industry, for instance for its addictive effect at the lowest possible rates. The addition of diammonium phosphate and urea produces an alcalinization of the pH of cigarette smoke, and promotes the absorption and the trans-membrane passage of nicotine. The taste, the smell of smoke, and the visual aspect of the pack of cigarettes are also sensory components that promote addiction. Finally, menthol, sugar, cocoa and liquorice added to cigarettes also play a role in dependence and addiction to cigarettes by, for instance, making an anesthetic effect on the airways.

Ecotoxicity Values · 5 items

LC50; Species: Grammarus pseudolimnaeus (Northern spring amphipod) (mature); Conditions: static, 18 °C; Concentration: 52 mg/L for 96 hr (95% Confidence interval: 48 to 68 mg/L)

LC50; Species: Grammarus pseudolimnaeus (Northern spring amphipod) (mature); Conditions: static, 18 °C; Concentration: 40 mg/L for 96 hr (95% Confidence interval: 32 to 46 mg/L)

LC50; Species: Coho salmon; Conditions: static, 11 °C; Concentration: 320 mg/L for 96 hr (95% Confidence interval: 279-367 mg/L)

LC50; Species: Coho salmon; Conditions: static, 11 °C; Concentration: 245 mg/L for 96 hr (95% Confidence interval: 216 to 277 mg/L)

For more Ecotoxicity Values (Complete) data for DIAMMONIUM HYDROGEN PHOSPHATE (14 total), please visit the HSDB record page.

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.
Exposure RoutesThe substance can be absorbed into the body by inhalation of its aerosol.
Toxicity Summary · 4 items

The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Ammonium Phosphate...

Safe for use in cosmetics, with qualifications

The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Diammonium Phosphate...

Safe for use in cosmetics, with qualifications

Ecotoxicity Excerpts · 2 items

/AQUATIC SPECIES/ Acute toxicity to five freshwater fishes and a scud was determined in static tests. 96 hr LC50 ranged from 40 mg/L for scuds to 1500 mg/L for fingerling fish. In salmon and trout, yolk-sac fry were more susceptible than swim-up fry.

/AQUATIC SPECIES/ The effects of two commonly used fertilizers, diammonium phosphate and urea, on hematological parameters (hemoglobin, red blood cell count, hematocrit, and total leucocyte count) of fresh water fish Clarias batrachus were studied. The toxic effect of diammonium phosphate was more pronounced than that of urea. The toxic effect of diammonium phosphate resulted in a sudden fall of hematological parameters--Hb, red blood cell count, Hct--at higher concentrations, and at lower concentrations gradual decreases were seen over comparatively longer durations. In urea intoxication, slight decreases in the three parameters were seen at lower concentrations during shorter intervals, while at higher concentrations, significant decreases during shorter intervals were observed. Total leucocyte count increased during toxicity with both fertilizers, but higher elevations in total leucocyte count were produced by diammonium phosphate than by urea.

Regulatory information

FDA Requirements · 3 items

The food additive diammonium phosphate may be safely used in ruminant feed in accordance with the following prescribed conditions: (a) The food additive is the product resulting from the neutralization of feeding-phosphoric-acid or defluorinated wet-process phosphoric acid with anhydrous ammonia. It contains not less than 106.25% equivalent crude protein (nitrogen X 6.25) and 20% phosphorus. It contains not more than the following: 1 part fluorine to 100 parts phosphorus; 75 ppm arsenic (as As); 30 ppm heavy metals, as lead (Pb). (b) It is used in ruminant feeds as a source of phosphorus and nitrogen in an amt that supplies not more than 2% of equivalent crude protein in the total daily ration.

Ammonium phosphate (mono-, and dibasic) used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

FIFRA Requirements · 1 item

Residues of diammonium phosphate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: buffer, surfactant. Limit: none.

Safety data

wgk
1
tsca
TSCA listed
ridadr
UN3264
hs_code
31054000
Toxicity
LD50 orally in Rabbit: 5750 mg/kg LD50 dermal Rabbit > 7940 mg/kg
risk_code
36/37/38

Chemistry & industry

Pharmacology

Bionecessity · 1 item

Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions. /Phosphate/

Metabolism/Metabolites · 2 items

In the animal body, diphosphate is formed from adenosyl triphosphate (ATP) in many enzymatic reactions. It is either utilized by entering phosphorolytic reactions, or it is hydrolysed by an inorganic diposphatase to monophosphate. /Diphosphate/

A defect in phosphate metabolism occurs in a variety of diseases. ... Rickets ... Osteomalacia ... Primary or Secondary Hyperparathyroidism ... Chronic Renal Failure. /Phosphates/

MeSH Pharmacological Classification · 2 items

Substances or mixtures that are added to the soil to supply nutrients or to make available nutrients already present in the soil, in order to increase plant growth and productivity.

Substances used in the processing or storage of foods or animal feed including ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS; EXCIPIENTS and other similarly used substances. Many of the same substances are used as PHARMACEUTIC AIDS.

Absorption, Distribution and Excretion · 2 items

Ingested diphosphate is readily converted to monophosphate; no diphosphate was found in feces or urine of rats treated with diets containing up to 5% tetrasodium diphosphate. In these experiments diphosphate was almost completely absorbed by the gut and excreted as monophosphate in the urine. /Diphosphate/

/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

Uses & manufacturing

Uses · 6 items

CIR ingredient: Ammonium Phosphate

CIR ingredient: Diammonium Phosphate

Used in fireproofing (textiles, paper, wood, and vegetable fibers), impregnating lamp wicks; preventing afterglow in matches, soldering, purifying sugar, inhibiting corrosion, and fertilizing; [Merck Index] Used as a food additive and livestock supplement; [CHEMINFO]

Soldering [Category: Heat or Machine]

Fireproofing textiles, paper, wood, and vegetable fibers; impregnating lamp wicks; preventing afterglow in matches; flux for soldering tin, copper, brass, and zinc; purifying sugar; in yeast cultures; in dentifrices; in corrosion inhibitors; in fertilizers.

A common fire-extinguishing ingredient in ABC-type dry-powder extinguishers ... Used as flame retardants for cellulosic materials, including plywood, papers, and fabrics, to prevent afterglow in matches and to control forest fires /Ammonium phosphates/

ImpuritiesWet process DAP: iron, aluminum and magnesium.
U.S. Exports · 3 items

(1972) 1.7X10+12 GRAMS (INCL MONOAMMONIUM)

(1975) 2.20X10+12 GRAMS

About 5.8 million tons for crop year 1995 /Ammonium phosphates/

U.S. Imports · 3 items

(1972) 4.6X10+11 GRAMS (INCL MONOAMMONIUM)

(1975) 8.31X10+10 GRAMS

Crop year 1995, negligible) /Ammonium phosphates/

U.S. Production · 6 items

2023: 4,000,000,000 - <5,500,000,000 lb

(1972) 5.9X10+12 GRAMS (INCL MONOAMMONIUM)

(1975) 5.17X10+12 GRAMS

CHEMICAL PROFILE: Ammonium phosphates. Demand: 1985-1986 (Fertilizer year): 10.07 million tons; 1986-1987 /projected/: 10.32 million tons; 1990-1991 /projected/: 12.1 million tons. /Ammonium phosphates/

CHEMICAL PROFILE: Ammonium phosphates. Demand: 1988-1989 (fertilizer year): 15.25 million tons; 1989-1990 /projected/: 15.55 million tons; 1993-1994 /projected/: 17.0 million tons. (Includes exports, but not imports, which are negligible.) /Ammonium phosphates/

For more U.S. Production (Complete) data for DIAMMONIUM HYDROGEN PHOSPHATE (9 total), please visit the HSDB record page.

Consumption Patterns · 5 items

(INCL MONOAMMONIUM PHOSPHATE) 97% FOR FERTILIZERS; 1% FOR FIRE CONTROL; 1% FOR LIVESTOCK FEEDS; 1% IN MISCELLANEOUS APPLICATIONS (1972)

CHEMICAL PROFILE: Ammonium Phosphates. 100% fertilizers: diammonium phosphate 87% (49% domestic, 51% export); monoammonium phosphate 13% (60% domestic, 40% export). /Ammonium phosphates/

CHEMICAL PROFILE: Ammonium phosphates. 100% fertilizers: diammonium phosphate 85%; monoammonium phosphates 15%. Exports account for 50% of total ammonium phosphates production. /Ammonium phosphates/

Fertilizer, 98% (DAP, 70%; MAP 23%, other solid ammonium phosphates, 5%); industrial uses, 1.5%; animal feed, 0.5%. /Ammonium phosphates/

During the year ending June 30, 1990, DAP represented 38% of total U.S. fertilizer P2O5 usage.

Applications · 5 items

UsesMonoammonium phosphate (MAP) is a widely used source of P and N. It is made of two constituents common in the fertilizer industry and has the highest P content of any common solid fertilizer. MAP has been an important granular fertilizer for many years. It is water soluble and dissolves rapidly in soil if adequate moisture is present. Upon dissolution, the two basic components of the fertilizer separate again to release NH4 + and H2PO4 - . Both of these nutrients are important to sustain healthy plant growth. The pH of the solution surrounding the granule is moderately acidic, making MAP an especially desirable fertilizer in neutral and high pH soils. Agronomic studies show that there is no significant difference in P nutrition from various commercial P fertilizers under most conditions. Leavening agent, dough regulator, yeast food, brewing fermentation additives and buffer in the food industry. Animal feed additives. Nitrogen and phosphorus compound fertilizer with highly efficient. Fire retardant for wood, paper, fabric, dispersant for fiber processing and dyeing industry, glaze for enamel, cooperating agent for fire retardant coating, decontamination agent for match stalk and candle core. In indurstis of printing plate and pharmaceutical manufacturing.

UsesUsed as buffer solutions.

UsesAmmonium dihydrogen phosphate is a general purpose food additive which is readily soluble in water. A 1% solution has a ph of 4.3–5.0. It is used as a dough strengthener and leavening agent in baked goods and as a firming agent and ph control agent in condiments and puddings. It is also used in baking powder with sodium bicarbonate and as a yeast food.

UsesAs baking powder with sodium bicarbonate; in fermentations (yeast cultures, etc.); fireproofing of paper, wood, fiberboard, etc.

General DescriptionAmmonium phosphate monobasic (APM) is an inorganic salt widely used in fertilizer, baking powder and yeast production. It is also employed as an agent to control pH of a solution and in corrosion inhibition. APM can be prepared by reacting phosphoric acid with anhydrous ammonia maintaining the pH below 5.8. The change in some of the physical characteristics on its addition to a high carbonate containing unfired and fired illitic shale has been studied.

Preparation methods

PreparationPreparative method similar to its dibasic salt; obtained by reaction of equimolar amounts of ammonia and phosphoric acid:NH3 + H3PO4 → (NH4)H2PO4.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
韶远科技(上海)有限公司021-50795510 4000665055 · [email protected]
北京康普汇维科技有限公司010-67777729 18810111057 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]

Additional notes

DefinitionChEBI: The ammonium salt of phosphoric acid (molar ratio 1:1).

Related reactions

47 records

Linked notes

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