2-Aminoadamantane hydrochloride (HCID 25331)

Names & identifiers

Preferred name: 2-Aminoadamantane hydrochloride
IUPAC: adamantan-2-amine;hydrochloride
English name: 2-Adamantanamine hydrochloride
Molecular formula: C10H17N.ClH
Molecular weight: 187.71

Names & synonyms

2-Aminoadamantane hydrochlorideRefChem:8501710523-68-9adamantan-2-amine hydrochloride2-Adamantanamine hydrochloride2-Adamantylamine hydrochlorideadamantan-2-amine;hydrochloride2-Adamantanamine HClMFCD000747432-ADAMANTANAMINE, HYDROCHLORIDEAdamantan-2-ylamine hydrochloride2-adamantan amine HCl

Show more names

2-AdamantylamineHClIFLAB-BB F1928-00242-AMINOADAMANTANEHCL2-admantylamine hydrochloride2-Adamantanamin hydrochloride2-ADAMANTANAMINE HYROCHLORIDE

Adamantan-2-amine HClAKOS000104803AKOS017343998SY011241A0718(1r,3r,5r,7r)-adamantan-2-amine hydrochlorideEINECS 234-074-22-Adamantylam

Database identifiers

CAS: 10523-68-9
PubChem CID: 25331
DTXSID: DTXSID60147021
ChEMBL: CHEMBL447911
EC Number: 234-074-2

Properties

Computed structural properties

Topological polar surface area: 26 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 12
Formal charge: 0
Complexity: 148

Physicochemical properties

Melting point: 300 °C · >300 °C(lit.)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Crystalline Powder
color: White
Water Solubility: soluble
BRN: 4297901 · 4297901
InChI: InChI=1/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10;
InChIKey: WLDWDRZITJEWRJ-ZDAMNCSYNA-N
SMILES: C1(N)[C@@]2([H])C[C@]3([H])C[C@]([H])(C2)C[C@@]1([H])C3.Cl |&1:2,5,8,12,r|
CAS DataBase Reference: 10523 · 10523-68-9(CAS DataBase Reference)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi,Xn
Risk Statements: 36 · 36/37/38-22
Safety Statements: 26 · 26-36-36/37/39-22
WGK Germany: 3 · 3
RTECS: 4375100 · AU4375100
F: 10 · 10
HazardClass: IRRITANT
HS Code: 29213000 · 29213000
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

Safety data

F: 10
PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
rtecs: AU4375100
hs_code: 29213000
risk_code: 36/37/38-22
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi,Xn
safety_code: 26-36-36/37/39-22
hazard_class: IRRITANT
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Chemistry & industry

Applications · 3 items

Uses2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders.

Uses2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

General DescriptionThe HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.