Hydroxylamine, nitrate
Basic information
- CAS
13465-08-2- Standard SMILES
O=[N+]([O-])[O-].[NH3+]O- InChIKey
CRJZNQFRBUFHTE-UHFFFAOYSA-N- Molecular formula
- H4N2O4
- Average molar mass
- 96.04 g/mol
- Monoisotopic mass
- 96.01710661
Overview
Hydroxylammonium nitrate (HAN) is the salt of hydroxylamine and nitric acid. It is being developed as a potential rocket propellant and is sometimes used in nuclear reprocessing as a plutonium reductant. Nitrite is a toxic compound known to cause methemoglobinemia. (L1137, L1628)
Names & identifiers
- Preferred name
- Hydroxylamine, nitrate
- IUPAC
- hydroxyazanium nitrate
- English name
- Hydroxylamine nitrate
- Molecular formula
- H4N2O4
- Molecular weight
- 96.04
Names & synonyms
hydroxyazanium;nitrateHydroxylamine, nitrateHydroxylamine, nitrate (salt)Hydroxylamine, nitrate (1:1)EINECS 236-691-2EC 236-691-2NS00086997Q424954HANHydroxylamine nitratehydroxyazanium,nitrateHYDROXYLAMMONIUM OXALATE
Show more names
HYDROXYLAMMONIUM NITRATEhydroxylamine,nitrate(salt)Hydroxylamine nitrate solutionHydroxylamine solution nitrateHydroxylammonium nitrate solutionHYDROXYLAMINENITRATE,AQUEOUSSOLUTION
Database identifiers
- CAS
13465-08-2- PubChem CID
- 26045
Properties
Computed structural properties
- Topological polar surface area
- 111 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 20.8
Physicochemical properties
- Density
- 1.09 g/mL · 1.09 g/mL at 20 °C
- vapor pressure
- 9.33 hPa · 9.33hPa at 25℃
- Viscosity
- 0.896 mm2/s · 0.896mm2/s
- Water Solubility
- 587 g/L · 587g/L at 20℃
- LogP
- -3.6 · -3.6
- CAS DataBase Reference
- 13465 · 13465-08-2
- EPA Substance Registry System
- Hydroxylamine nitrate (13465-08-2)
- Symbol(GHS)
- 1 · GHS01,GHS06,GHS08,GHS09
- Signal word
- Danger
- Hazard statements
- 201 · H201-H302-H311-H315-H319-H317-H351-H373-H400
- Precautionary statements
- 210 · P210-P230-P234-P240-P250-P280-P264-P270-P261-P272-P201-P202-P260-P273-P301+P312-P330-P302+P352-P312-P361+P364-P332+P313-P362+P364-P305+P351+P338-P337+P313-P333+P313-P308+P313-P314-P391-P401-P405-P501
- Hazard Codes
- Xn,C,Xi,N
- Risk Statements
- 1 · 1-22-36/37/38-43-48/22-34-20/21/22-50
- Safety Statements
- 26 · 26-36/37-45-36/37/39-35-61
- RIDADR
- 1759 · 1759
- WGK Germany
- 3 · 3
- TSCA
- TSCA listed
- HazardClass
- 8 · 8
- PackingGroup
- III
- REACH Registrations
- Active
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Toxicology
Treatment
Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613)
Health EffectsNitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137)
Exposure RoutesOral (L1137) ; inhalation (L1137)
Toxicity Summary
Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)
Signs and Symptoms
Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137)
Carcinogen ClassificationIngested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135)
Safety data
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- 1759
- risk_code
- 1-22-36/37/38-43-48/22-34-20/21/22-50
- Signal word
- Danger
- Symbol(GHS)
- GHS01,GHS06,GHS08,GHS09
- hazard_code
- Xn,C,Xi,N
- safety_code
- 26-36/37-45-36/37/39-35-61
- hazard_class
- 8
- packing_group
- III
- Hazard statements
- H201-H302-H311-H315-H319-H317-H351-H373-H400
- REACH Registrations
- Active
- Precautionary statements
- P210-P230-P234-P240-P250-P280-P264-P270-P261-P272-P201-P202-P260-P273-P301+P312-P330-P302+P352-P312-P361+P364-P332+P313-P362+P364-P305+P351+P338-P337+P313-P333+P313-P308+P313-P314-P391-P401-P405-P501
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137)
Related reactions
5 records
Compound notes
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