Basic information
- CAS
140716-14-9- Standard SMILES
CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O- InChIKey
VOMQYBALZJIZLK-URSBCDAASA-N- Molecular formula
- C57H65N9O8S
- Average molar mass
- 1,036.2 g/mol
- Monoisotopic mass
- 1,035.46768124
Overview
amino acid sequence given in first source; a non-competitive antagonist of substance P (6-11)
Names & identifiers
- Preferred name
- Awl 60
- IUPAC
- (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
- English name
- AWL 60
- Molecular formula
- C57H65N9O8S
- Molecular weight
- 1036.2465
Names & synonyms
Awl 60140716-14-9Awl-60DTXSID40161467L-Methioninamide, L-tyrosyl-L-prolyl-D-phenylalanyl-L-phenylalanyl-D-phenylalanyl-D-tryptophyl-RefChem:115817DTXCID1083958Tyr-pro-D-phe-phe-D-phe-D-trp-metnh2Tyrosyl-prolyl-phenylalanyl-phenylalanyl-phenylalanyl-tryptophyl-methioninamide(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2R)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamideorb1702524AKOS040746600
Show more names
CS-0107640T25122L-Tyrosyl-L-prolyl-D-phenylalanyl-L-phenylalanyl-D-phenylalanyl-D-tryptophyl-L-methioninamide
Properties
Computed structural properties
- XLogP
- 5.4
- Topological polar surface area
- 296 Ų
- Hydrogen bond donors
- 9
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 25
- Heavy atoms
- 75
- Formal charge
- 0
- Complexity
- 1,870
Chemistry & industry
Applications
DescriptionAwl 60 is a non-competitive antagonist of substance P (6-11).
UsesAWL 60 is a compound with SP antagonist and weak opioid agonist properties, which can antagonize SP-agonists in vitro and attenuate the decrease in blood pressure caused by SP-agonists in vivo.
Suppliers2 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
0 records
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Compound notes
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