HuagongsheHuagongshe Chemistry Print Report · For research reference only
Awl 60
AWL 60 · Tyr-pro-D-phe-phe-D-phe-D-trp-metnh2
Identifiers & Physical Properties
| CAS No. | 140716-14-9 |
|---|---|
| Molecular formula | C57H65N9O8S |
| Average molar mass | 1,036.2 g/mol |
| Monoisotopic mass | 1,035.46768124 g/mol |
| SMILES | CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O |
| InChIKey | VOMQYBALZJIZLK-URSBCDAASA-N |
| PubChem CID | 3083326 |
| DTXSID | DTXSID40161467 |
Chemical & Physical Properties
| XLogP | 5.4 |
|---|---|
| Topological polar surface area | 296 |
| Hydrogen bond donors | 9 |
| Hydrogen bond acceptors | 10 |
| Rotatable bonds | 25 |
| Heavy atoms | 75 |
| Formal charge | 0 |
| Complexity | 1,870 |
Applications & Uses
Description
Awl 60 is a non-competitive antagonist of substance P (6-11).
Uses
AWL 60 is a compound with SP antagonist and weak opioid agonist properties, which can antagonize SP-agonists in vitro and attenuate the decrease in blood pressure caused by SP-agonists in vivo.