2-Amino-5-iodo-3-nitropyridine (HCID 3384468)

Names & identifiers

Preferred name: 2-Amino-5-iodo-3-nitropyridine
IUPAC: 5-iodo-3-nitropyridin-2-amine
English name: 2-AMINO-5-IODO-3-NITROPYRIDINE
Molecular formula: C5H4IN3O2
Molecular weight: 265.01

Names & synonyms

25391-57-52-Amino-5-iodo-3-nitropyridineDTXSID10391991RefChem:464616DTXCID60342852626-879-65-iodo-3-nitropyridin-2-amineMFCD040384645-iodo-3-nitro-pyridin-2-amine2-Pyridinamine, 5-iodo-3-nitro-5-Iodo-3-nitro-2-aminopyridineSCHEMBL1601280

Show more names

Zinc042029185-iodo-3-nitro-2-pyridinamine2-PYRIDINAMINE,5-IODO-3-NITRO2-Amino-3-nitro-5-iodopyridine5-IODO-3-NITRO-PYRIDIN-2-YLAMINE2-Amino-5-iodo-3-nitropyridine 95+%2-AMINO-5-IODO-3-NITROPYRIDINE ISO 9001：2015 REACH

5-iodo-3-nitro-2-pyridylamineSBB065277AKOS005257300PB233792-Amino-5-iodo-3-nitropyridine, 97%DS-12470SY041319DB-046691

Database identifiers

CAS: 25391-57-5
PubChem CID: 3384468
DTXSID: DTXSID10391991
EC Number: 626-879-6

Properties

Computed structural properties

XLogP: 1.5
Topological polar surface area: 84.7 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 4
Rotatable bonds: 0
Heavy atoms: 11
Formal charge: 0
Complexity: 160

Physicochemical properties

Melting point: 215 · 215-219 °C (lit.)
Boiling point: 365.4 · 365.4±42.0 °C(Predicted)
Density: 2.229 · 2.229±0.06 g/cm3(Predicted)
storage temp.: 2 · under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 0.41 · 0.41±0.49(Predicted)
Appearance: Light yellow to yellow Solid
InChI: 1S/C5H4IN3O2/c6-3-1-4(9(10)11)5(7)8-2-3/h1-2H,(H2,7,8)
InChIKey: MDJUWRHSXKZSOJ-UHFFFAOYSA-N
SMILES: Nc1ncc(I)cc1[N+]([O-])=O
CAS DataBase Reference: 25391 · 25391-57-5(CAS DataBase Reference)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 302 · H302-H315-H317-H319-H335
Precautionary statements: 261 · P261-P280-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes: Xn,Xi
Risk Statements: 22 · 22-36/37/38-43
Safety Statements: 26 · 26-36/37
WGK Germany: 3 · 3
Hazard Note: Irritant
HS Code: 2933399990 · 2933399990
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 4 OralEye · Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2Skin Sens. 1STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (100%)；Skin Irrit. 2 (100%)；Skin Sens. 1 (100%)；Eye Irrit. 2 (100%)；STOT SE 3 (100%)

Safety data

PPE: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
wgk: 3
hs_code: 2933399990
risk_code: 22-36/37/38-43
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xn,Xi
hazard_note: Irritant
safety_code: 26-36/37
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H302-H315-H317-H319-H335
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2Skin Sens. 1STOT SE 3
Precautionary statements: P261-P280-P305+P351+P338

Chemistry & industry

Applications · 1 item

Uses2-Amino-5-iodo-3-nitropyridine is used in the synthetic preparation of disubstituted pyridinyl azabicyclo heptanes as epibatidine analogs. These analogs are evaluated for its affinity for nicotinic acetylcholine receptors via in vitro and antinociceptive properties via in vivo in rats.