Basic information
- Standard SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F- InChIKey
MGCCHNLNRBULBU-WZTVWXICSA-N- Molecular formula
- C21H28F3N3O7
- Average molar mass
- 491.5 g/mol
Overview
Flunixin meglumine is an organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; used in veterinary medicine for treatment of horses, cattle and pigs. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It contains a flunixin(1-).
Names & identifiers
- Preferred name
- Flunixin Meglumine
- IUPAC
- (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol;2-[2-methyl-3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid
Names & synonyms
FLUNIXIN MEGLUMINE42461-84-7BanamineFlumeglumineSch 14714 meglumineFlunixin-SFlunixin N-methylglucanineSch-14714 meglumine8Y3JK0JW3UFlunixin meglumine saltFlunazineNSC-759583
Show more names
CHEBI:761442-((2-Methyl-3-(trifluoromethyl)-phenyl)amino)-3-pyridinecarboxylic acid with meglumine compoundedDTXCID9025584FlunineVetaMegBanamine PasteFlunazine-SVetameg S
Database identifiers
- CAS
42461-84-7- PubChem CID
- 39212
- ChEMBL
CHEMBL1733447- ChEBI
CHEBI:76144- UNII
- 8Y3JK0JW3U
- EC Number
- 255-836-0
Properties
Computed structural properties
- Topological polar surface area
- 175 Ų
- Hydrogen bond donors
- 8
- Hydrogen bond acceptors
- 13
- Rotatable bonds
- 9
- Heavy atoms
- 34
- Formal charge
- 0
- Complexity
- 510
Experimental & physicochemical properties
DrugsDEA NFLIS-Drug Category -> Analgesics
Animal DrugsActive Ingredients (Flunixin Meglumine) -> FDA Greenbook
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 0.5% (1 of 215) of reports.
Danger
H301 (79.5%): Toxic if swallowed [Danger Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P320, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 215 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationFlunixin meglumine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - D-Glucitol, 1-deoxy-1-(methylamino)-, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (79.5%)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Drugs that are used to reduce body temperature in fever.
Uses & manufacturing
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Related reactions
9 records
Linked notes
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