Propylene Glycol → Florfenicol Flunixin

HRID 1666772

Reaction equation

HRID 1666772 reaction equation
C(O)C(O)C.[CH3:6][S:7]([C:10]1[CH:11]=[CH:12][C:13]([C@@H:16]([OH:26])[C@H:17]([NH:20][C:21]([CH:23]([Cl:25])[Cl:24])=[O:22])[CH2:18][F:19])=[CH:14][CH:15]=1)(=[O:9])=[O:8].[CH3:27][C:28]1[C:33]([NH:34][C:35]2[N:40]=[CH:39][CH:38]=[CH:37][C:36]=2[C:41]([OH:43])=[O:42])=[CH:32][CH:31]=[CH:30][C:29]=1[C:44]([F:47])([F:46])[F:45].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>CN1CCCC1=O>[CH3:6][S:7]([C:10]1[CH:11]=[CH:12][C:13]([C@@H:16]([OH:26])[C@H:17]([NH:20][C:21]([CH:23]([Cl:25])[Cl:24])=[O:22])[CH2:18][F:19])=[CH:14][CH:15]=1)(=[O:9])=[O:8].[CH3:27][C:28]1[C:33]([NH:34][C:35]2[N:40]=[CH:39][CH:38]=[CH:37][C:36]=2[C:41]([OH:43])=[O:42])=[CH:32][CH:31]=[CH:30][C:29]=1[C:44]([F:46])([F:45])[F:47]

Participants

5

Reactant 3

HCID 1030Propylene GlycolHCID 39212Flunixin MeglumineHCID 114811Florfenicol

Product 1

HCID 86602307Florfenicol Flunixin

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The N-methyl-2-pyrrolidone, propylene glycol and approximately 90% of the PEG 300 required were charged to the compounding vessel and mixed well. The florfenicol and flunixin meglumine were added with mixing until all solids were dissolved. The volume was adjusted with the remaining PEG 300.

Workup

  1. additionmixed well
  2. additionwith mixing until all solids
  3. dissolutionwere dissolved

Sources & evidence

ORD record
ord-ac75156d5f6e418b8b5c567e68961f72
Source dataset
uspto-grants-2011_10
Patent number
US08044102B2

Linked notes

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