HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Morpholinopyridine
4-(pyridin-4-yl)Morpholine · SKL333 · 4-Morpholinopyridine · 4-(4-PYRIDYL)MORPHOLINE · 4-MORPHOLINOPYRIDINE 97% · 4-(4-Pyridinyl)Morpholine · 4-(4-Pyridyl)morpholine>Morpholine, 4-(4-pyridinyl)- · 4-(4-Morpholinyl)pyridine, 97%
Identifiers & Physical Properties
| CAS No. | 2767-91-1 |
|---|---|
| Molecular formula | C9H12N2O |
| Average molar mass | 164.2 g/mol |
| Monoisotopic mass | 164.09496301 g/mol |
| SMILES | c1cc(N2CCOCC2)ccn1 |
| InChIKey | QJWQYVJVCXMTJP-UHFFFAOYSA-N |
| PubChem CID | 4145413 |
| ChEMBL | CHEMBL1643354 |
| EC No. | 627-998-6 |
| DTXSID | DTXSID20399887 |
Chemical & Physical Properties
| XLogP | 0.6 |
|---|---|
| Topological polar surface area | 25.4 |
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 1 |
| Heavy atoms | 12 |
| Formal charge | 0 |
| Complexity | 128 |
| Melting point | 102-108 °C (lit.) |
| Boiling point | 301.3±32.0 °C(Predicted) |
| Density | 1.124±0.06 g/cm3(Predicted) |
| Storage conditions | Sealed in dry,Room Temperature |
| Solubility | soluble in Methanol |
| pKa (acidity coefficient) | 7.97±0.26(Predicted) |
| Physical state | Powder |
| Color | Yellow to orange |
| InChI | InChI=1S/C9H12N2O/c1-3-10-4-2-9(1)11-5-7-12-8-6-11/h1-4H,5-8H2 |
| InChIKey | QJWQYVJVCXMTJP-UHFFFAOYSA-N |
| SMILES | N1(C2C=CN=CC=2)CCOCC1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319-H335 |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Target organs | Respiratory system |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard symbols | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
| Water hazard class (WGK) | 3 |
| Customs code | 2934999090 |
| Storage class | 11 - Combustible Solids |
| Hazard class | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
Safety & Regulations
| GHS classification | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Water hazard class (WGK) | 3 |
| Customs code | 2934999090 |
| Risk statements (R) | 36/37/38 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xi |
| Safety statements (S) | 26-36 |
| Storage class | 11 - Combustible Solids |
| Target organs | Respiratory system |
| GHS hazard statements | H315-H319-H335 |
| Hazard class | Eye Irrit. 2Skin Irrit. 2STOT SE 3 |
| GHS precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
Applications & Uses
Uses
4-Morpholinopyridine may be used in the synthesis of 1-alkyl-4-morpholinopyridinium halides. It may also be used as a secondary enhancer to improve the chemiluminescence of horseradish peroxidase (HRP) catalyzed oxidation of luminol.
General Description
4-Morpholinopyridine (MORP) can be synthesized by the reduction of its 1-oxide. It undergoes morpholine ring contraction on reacting with trimethylsilylmethyllithium (TMSCH2Li).