Triprolidine hydrochloride monohydrate
TRIPROLIDINE HCL MONOHYDRATE · rate,stereoisomer · TRIPROLIDINE HCL USP · trans-TriprolidineHCl · Tripolidine Hydrochloride · Triprolidine hydrochloride · Triprolidine Hydrochlorise · TRIPROLIDINEHYDROCHLORIDE,USP
Identifiers & Physical Properties
| CAS No. | 6138-79-0 |
|---|---|
| Molecular formula | C19H22N2.ClH.H2O |
| Average molar mass | 332.9 g/mol |
| Monoisotopic mass | 332.1655411 g/mol |
| SMILES | Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl.O |
| InChIKey | CUZMOIXUFHOLLN-UMVVUDSKSA-N |
| PubChem CID | 5284472 |
| ChEMBL | CHEMBL3188034 |
| ChEBI | CHEBI:32265 |
| EC No. | 627-740-2 |
| DTXSID | DTXSID0021410 |
Chemical & Physical Properties
| Topological polar surface area | 17.1 |
|---|---|
| Hydrogen bond donors | 2 |
| Hydrogen bond acceptors | 3 |
| Rotatable bonds | 4 |
| Heavy atoms | 23 |
| Formal charge | 0 |
| Complexity | 335 |
| Solubility | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)alcohol: soluble1 in 1.5 of solvent>=10 g/100 mL at 20 ºC |
| Melting point | 239 to 248 °F (NTP, 1992)115-120°C |
| Physical Description | Triprolidine hydrochloride monohydrate is an odorless white crystalline powder. Bitter taste. (NTP, 1992) |
| Storage conditions | 2-8°C |
| Physical state | Solid |
| Color | White to Off-White |
| Merck | 13,9817 |
| Stability | Stable, but discolours in light. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H31H/b18-11+ |
| InChIKey | WYUYEJNGHIOFOC-NWBUNABESA-N |
| SMILES | C(=C/CN1CCCC1)(\C1=NC=CC=C1)/C1C=CC(C)=CC=1.Cl |
| LogP (partition coefficient) | 4.223 (est) |
| CAS DataBase Reference | 6138-79-0(CAS DataBase Reference) |
| FDA 21 CFR | 341.12 |
| FDA UNII | YAN7R5L890 |
| EPA Substance Registry System | Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H302-H315-H319-H335 |
| GHS precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Target organs | Respiratory system |
| Personal protective equipment (PPE) | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard symbols | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
| Water hazard class (WGK) | 3 |
| RTECS number | UT7658000 |
| Customs code | 2933399090 |
| Storage class | 11 - Combustible Solids |
| Hazard class | Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3 |
Safety & Regulations
| GHS classification | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 96 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatory information | Pyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate: Does not have an individual approval but may be used under an appropriate group standard |
| Other safety information | IMAP assessments - Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-: Environment tier I assessment |
| Fire hazards | Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992) |
| Health hazards | SYMPTOMS: Symptoms of exposure to this compound may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea. (NTP, 1992) |
| Reactive group | Amines, Phosphines, and Pyridines |
| Reactivity Profile | TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE discolors on exposure to light. It is an acidic salt and can neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions. |
| Air and Water Reactions | Water soluble. |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
Applications & Uses
Uses
anticholinergic (opthalmic)
Uses
trans-Triprolidine Hydrochloride is a potent H1 receptor antagonist. Anti-histamines.
Uses
TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
General Description
Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.
General Description
Odorless white crystalline powder. Bitter taste.