Oleyl Alcohol

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Residues of oleyl alcohol are exempted from the requirement of a tolerance when used as a cosolvent (limit: 15%) in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Hydrophilic and lipophilic formulations of naproxen were prepared, and the influence of the excipients in the formulations on the ulcerogenic potential of naproxen was investigated in rats. Doses of naproxen suspensions ranging from 3.125-100 mg/kg were administered to fasted rats and excised stomachs were examined macroscopically for the incidence and severity of lesions. Results were expressed as the 50% ulceration dose. Results of the study showed that a lipophilic formulation containing oleyl alcohol provided the greatest gastric protection.

Long-chain fatty acids are important nutrients, but obesity is the most common nutritional disorder in humans. In this study /the authors/ investigated the effect of oleyl alcohol on the intestinal long-chain fatty acid absorption in rats. ...[14C]Oleic acid and oleyl alcohol /was administered/ as lipid emulsion intraduodenally in unanesthetized lymph-cannulated rats and measured the lymphatic output of oleic acid. ... Lipid emulsion /was then administered/ with a stomach tube and ... the luminal and mucosal oleic acid residues /were measured/. Furthermore, rats were fed oleyl alcohol as a dietary component for 20 days, and fecal lipid and the weight of adipose tissues were measured. In lymph-cannulated rats, triglyceride and [14C]oleic acid output in the lymph were significantly lower in the presence of oleyl alcohol when compared with the absence of oleyl alcohol in a dose-dependent manner. The radioactivity remaining in the intestinal lumen was more strongly detected in rats that had been orally administered oleyl alcohol than in the controls. The feces of rats fed an oleyl-alcohol-added diet contained much higher amounts of lipids, and the weights of their adipose tissues were significantly lower than in the control group. These results suggest that oleyl alcohol inhibits the rat gastrointestinal absorption of long-chain fatty acids in vivo.

Studies of the influence of fatty acids, which were the component of intestinal mucosal lipids, on the permeability of several drugs across bilayer lipid membranes generated from egg phosphatidylcholine and intestinal lipid have been pursued. The permeability coefficients of p-aminobenzoic acid, salicylic acid and p-aminosalicylic acid (anionic-charged drug) increased when fatty acids such as lauric, stearic, oleic, linoleic and linolenic acid were incorporated into the bilayer lipid membranes generated from phosphatidylcholine. In the presence of methyl linoleate and oleyl alcohol, no enhancing effect on p-aminobenzoic acid transfer was obtained. The effect of fatty acids was more marked at pH 6.5 than at pH 4.5. In contrast, upon the addition of fatty acids to intestinal lipid membranes which originally contained fatty acids, the permeability coefficient of p-aminobenzoic acid tended to decrease, though the permeability through intestinal lipid membranes was larger than that of phosphatidylcholine membranes. The permeability of p-aminobenzoic acid across bilayer lipid membranes from intestinal phospholipids was significantly decreased to about equal that of phosphatidylcholine membranes, and reverted to the value of intestinal lipid membranes when fatty acids were added to intestinal phospholipids. It seemed reasonable to assume that free fatty acids in the intestinal neutral lipid fraction could contribute to the increase in the permeability of p-aminobenzoic acid. On the basis of above results, possible mechanisms for good absorbability of weakly acidic drugs from the intestine are discussed.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1.3X10+4(SRC), determined from a structure estimation method(2), indicates that oleyl alcohol is expected to be immobile in soil(SRC). Volatilization of oleyl alcohol from moist soil surfaces may be expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.6X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Oleyl alcohol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.3X10-5 mm Hg(SRC), determined from a fragment constant method(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Based on one microbial study, oleyl alcohol was found to be utilized as the sole carbon source by bacteria, yeast, and fungi(5). Although this study provides little insight into the rate of biodegradation in soil, it suggests that biodegradation in soil may be important(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1.23X10+4(SRC), determined from a structure estimation method(2), indicates that oleyl alcohol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.6X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 8 hours and 7.4 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 163 days if adsorption is considered(5). Alcohols are generally resistant to hydrolysis(6). According to a classification scheme(7), an estimated BCF of 420(SRC), from an estimated log Kow of 7.5(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is high(SRC). Based on one microbial study, oleyl alcohol was found to be utilized as the sole carbon source by bacteria, yeast, and fungi(10). Although this study provides little insight into the rate of biodegradation in water, it suggests that biodegradation in water may be important(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), oleyl alcohol, which has an estimated vapor pressure of 9.3X10-5 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase oleyl alcohol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.5 hrs(SRC), calculated from its rate constant of 7.8X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase oleyl alchol may be removed from the air by wet or dry deposition(SRC). The rate constant for the vapor-phase reaction of oleyl alcohol with ozone has been estimated as 1.3X10-16 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). This corresponds to an atmospheric half-life of about 2.1 hrs at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(4).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of oleyl alcohol can be estimated to be 1.3X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that oleyl alcohol is expected to be immobile in soil.

/SIGNS AND SYMPTOMS/ ... 34 patients (23.2%), showed a positive patch test to fatty alcohols, 33 of them to oleyl alcohol.

/SIGNS AND SYMPTOMS/ ... Subjects (51) allergic to wool wax alcohols were tested. ... Lauryl alcohol reacted in 9 cases and oleyl alcohol in 7 cases with reaction grade 2+ and 3+.

/CASE REPORTS/ ... patch tests using the components of the cutting fluid gave positive reactions to 2-amino-ethanol (141435) and oleyl-alcohol (143282).

/CASE REPORTS/ The aim of this study was to investigate the frequency of sensitization to fatty alcohols in a group of patients with suspected cosmetic or medicament contact dermatitis. From May 1992 to September 1995, we patch tested a series of 5 fatty alcohols on 146 patients. These included 108 females and 38 males aged from 13 to 72 years (mean age 42.5). These patients, who had previously been tested with the GIRDCA standard series, were selected because their clinical lesions or histories indicated topical preparations as the possible source of their contact dermatitis. High-grade fatty alcohols (> 99% pure) were used for testing. 34 patients (23.2%), 25 female and 9 male aged from 14 to 72 years, showed a positive patch test to fatty alcohols, 33 of them to oleyl alcohol. A total of 39 reactions were detected with 5 patients showing more than 1 positive reaction. Our results show that sensitization to oleyl alcohol is not rare in patients with contact dermatitis due to cosmetics or topical medicaments.

Oleyl alcohol was qualitatively detected in adult lake trout (Salvelinus namaycush) collected in 1977 from Lake Michigan in Charlevoix, MI and it was qualitatively detected in walleye (Stizostedion v. vitreum) from Lake St. Clair Anchor Bay, MI and Lake Erie Dunkirk, PA(1).

AEROBIC: Oleyl alcohol (10 g) was found to be utilized as the sole carbon source by bacteria (Pseudomonas) in 10 days at 30 °C and pH 6.8-7.0. In the same study, 10 g oleyl alcohol was utilized as the sole carbon source by 3 yeasts (Candida, Pichia, and an unknown) in 10 days at 30 °C and pH 6.8-7.0. It was also utilized by 3 fungi (Aspergillus, Penicillium, and an unknown) in 20 days at 20-25 °C and pH 5.5-5.6(1).

ANAEROBIC: Oleyl alcohol was reported to achieve 88.6 percent ultimate degradation in 84 days at 35 °C and pH of 6.5 to 7.3 using anaerobic sludge(1).

An estimated BCF of 420 was calculated for oleyl alcohol(SRC), using an estimated log Kow of 7.5(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC).

Residues of oleyl alcohol are exempted from the requirement of a tolerance when used as a cosolvent (limit: 15%) in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

CIR ingredient: Oleyl Alcohol

Present in fish oils; [Merck Index] Used to make its sulfuric esters (detergents and wetting agents) and in carbon paper, stencil paper, printing inks, and bath oils; Used as metal cutting lubricant, plasticizer, softener and lubricant for textiles, carrier for medicaments, thickener in hair colorants, solvent for fragrances, and emulsifying, opacifying, antifoam, and viscosity increasing agent; [HSDB]

Metal Machining [Category: Heat or Machine]

In bath oils

As a thickener in hair colorants

Chiefly in the manufacture of its sulfuric esters which are detergents and wetting agents, as an antifoam agent; metal cutting lubricant; in carbon paper, stencil paper, printing ink; as a plasticizer; for softening and lubricating textile fabrics; carrier for medicaments.

2023: 1,000,000 - <5,000,000 lb

This chemical is listed as a High Production Volume (HPV) (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

(1986) >1 million-10 million pounds

(1990) >1 million-10 million pounds

(1994) >1 million-10 million pounds

For more U.S. Production (Complete) data for OLEYL ALCOHOL (6 total), please visit the HSDB record page.

From butyl oleate by a Boweault-Blanc reduction with sodium and butyl alcohol; or from triolein by hydrogenation in the presence of zinc chromate. Purification by fractional crystallization at -40 °C from acetone, followed by distillation.

Prepared by catalytic hydrogenation under pressure of the methyl esters of unsaturated fatty acids; mixed catalysts containing zinc are employed, and the reaction conditions correspond to those for the production of saturated fatty alcohols.

Oleyl alcohol is sold by Henkel under the trade name HD-Ocenol. Other manufacturers are New Japan Chemical Co., Ashland Chem. Co., and Kedzierzyn, Poland.

Grade: Technical, commercial (80-90%) pure.

Aldol; Atallco O; Cachalot O-1; Lancol; Novol

Trade names: AEC Oleyl Alcohol; Dermaffine; Jeecol O; Lipocol O/95 ... Protachem OA 70/75; Sabonal 90/95; U-Tanol HD 80/85; U-Tanol HD 90/95; U-Tanol HD CG

For more Formulations/Preparations (Complete) data for OLEYL ALCOHOL (6 total), please visit the HSDB record page.

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives;Solvents

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Fragrance Ingredients

Flavoring Agents -> JECFA Flavorings Index

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Plastics Material and Resin Manufacturing

9-Octadecen-1-ol, (9Z)-: ACTIVE

Reported cosmetic categories: eye shadows; mascara; hair dyes and colors; blushers; lipstick

Reported product categories: ... Hair conditioners; hair straighteners ... moisturizing preparations; makeup preparations (not eye), misc.; body and hand preparations (excluding shaving preparations); skin care preparations, misc.; tonics, dressings, and other hair grooming aids ... eyeliners; foundations; bath soaps and detergents ... hair bleaches; hair sprays (aerosol fixatives); paste masks (mud packs); personal cleanliness products, misc.; suntan gels, creams, and liquids; suntan preparations, misc.