Basic information
- CAS
78191-00-1- Standard SMILES
CON(C)C(C)=O- InChIKey
OYVXVLSZQHSNDK-UHFFFAOYSA-N- Molecular formula
- C4H9NO2
- Average molar mass
- 103.12 g/mol
- Monoisotopic mass
- 103.06332853
Names & identifiers
- Preferred name
- N-Methoxy-N-methylacetamide
- IUPAC
- N-methoxy-N-methylacetamide
- English name
- N-Methoxy-N-methylacetamide
- Molecular formula
- C4H9NO2
- Molecular weight
- 103.12
Names & synonyms
N-Methoxy-N-methylacetamide78191-00-1N-Methyl-N-methoxyacetamideOYVXVLSZQHSNDK-UHFFFAOYSA-DTXSID10336948RefChem:163655DTXCID30288036InChI=1/C4H9NO2/c1-4(6)5(2)7-3/h1-3H3OYVXVLSZQHSNDK-UHFFFAOYSA-NMFCD00060098N-methoxy-N-methyl-acetamideN-Methoxyl-N-methylacetamide
Show more names
N-Methoxy-N-methylacetamidN-Methoxy-N-methyLMethoxy-N-methylacetamideN-METHOXY-N-METHLACETAMIDEN-Methoxy-N-methylacetamide>
Acetamide, N-methoxy-N-methyl-N-Methyl-N-methoxyacetamide; N,O-Dimethylacetohydroxamic Acid; N-Methoxy-N-methylacetamide;N-Acetyl-N,O-dimethylhydroxylamineN-methoxy N-methylacetamiden-methoxy-n-methyl acetamideN-methyl-N-methoxylacetamideN-methyl-N-methoxy-acetamideN-Methoxy- N-methylacetamide
Database identifiers
- CAS
78191-00-1- PubChem CID
- 537505
- DTXSID
DTXSID10336948- EC Number
- 628-920-3
- Nikkaji
- J208.742A
Properties
Computed structural properties
- XLogP
- -0.2
- Topological polar surface area
- 29.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 72.1
Physicochemical properties
- Boiling point
- 152 °C · 152 °C (lit.)
- Density
- 0.97 g/mL · 0.97 g/mL at 25 °C (lit.)
- refractive index
- 20 · n20/D 1.426(lit.)
- Flash point
- 121 °F · 121 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Liquid
- color
- Colorless
- Water Solubility
- Soluble
- InChI
- InChI=1S/C4H9NO2/c1-4(6)5(2)7-3/h1-3H3
- InChIKey
- OYVXVLSZQHSNDK-UHFFFAOYSA-N
- SMILES
- C(N(OC)C)(=O)C
- CAS DataBase Reference
- 78191 · 78191-00-1(CAS DataBase Reference)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 2 · GHS02
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 1.8% (1 of 55) of reports.
Warning
H226 (98.2%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 55 reports by companies from 4 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory InformationStatus: Active Update: 29-07-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/19218
Hazard Classes and CategoriesFlam. Liq. 3 (98.2%)
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 3
- ridadr
- UN 1993 3/PG 3
- hs_code
- 29280000
- risk_code
- 10
- Signal word
- Warning
- Symbol(GHS)
- GHS02
- safety_code
- 16-24/25
- hazard_class
- 3
- Storage Class
- 3 - Flammable liquids
- packing_group
- III
- Hazard statements
- H226
- Limited Quantities
- 5.0 L (1.3 gallons) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
Chemistry & industry
Applications
UsesN-Methoxy-N-methylacetamide, is a Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.
General DescriptionSimple Weinreb amide used in the synthesis of marine natural products myriaporone and usneoidone as a ketone synthon.
Preparation methods
PreparationN-Methoxy-N-methylacetamide can be prepared by reaction of Acetyl Chloride with commercially available N,O-Dimethylhydroxylamine hydrochloride in pyridine, followed by distillation at reduced pressure (65%).
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
203 records
Compound notes
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