Water → N-(6-acetyl-1,2,3,4-tetrahydronaphthalen-2-yl)-4-(oxolan-2-ylmethoxy)benzamide

HRID 103623

Reaction equation

HRID 103623 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[CH2:8][CH:7]([NH:12][C:13]([c:14]1[cH:15][cH:16][c:17]([O:20][CH2:21][CH:22]3[O:23][CH2:24][CH2:25][CH2:26]3)[cH:18][cH:19]1)=[O:27])[CH2:6][CH2:5]2.[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:35][O:36][N:37]([C:38]([CH3:39])=[O:40])[CH3:41].[Li:28][CH3:29].[Li:30][CH2:31][CH2:32][CH2:33][CH3:34].[OH2:42]>>[c:2]1([C:38]([CH3:39])=[O:40])[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[CH2:8][CH:7]([NH:12][C:13]([c:14]1[cH:15][cH:16][c:17]([O:20][CH2:21][CH:22]3[O:23][CH2:24][CH2:25][CH2:26]3)[cH:18][cH:19]1)=[O:27])[CH2:6][CH2:5]2

Participants

7

Reactant 6

HCID 962WaterHCID 8028TetrahydrofuranHCID 537505N-Methoxy-N-methylacetamideHCID 67544436N-(6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-(oxolan-2-ylmethoxy)benzamideHCID 178418339ButyllithiumHCID 178418348HCID 178418348, compound

Product 1

HCID 67546028N-(6-acetyl-1,2,3,4-tetrahydronaphthalen-2-yl)-4-(oxolan-2-ylmethoxy)benzamide

Sources & evidence

ORD record
ord-f19f1a1ae8a443939311275d67583d6e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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