CAS 56-18-8 Bis(3-aminopropyl)amine (HCID 5942)

Overview

3,3'-iminodipropylamine appears as a colorless liquid. Less dense than water. Flash point of 170 °F. Very irritating to skin and eyes, and may be toxic by ingestion. Used to make soaps, dyes, and pharmaceuticals.

Names & identifiers

Preferred name: Bis(3-aminopropyl)amine
IUPAC: N'-(3-aminopropyl)propane-1,3-diamine
English name: DIPROPYLENETRIAMINE
Molecular formula: C6H17N3
Molecular weight: 131.22

Names & synonyms

NorspermidineBis(3-aminopropyl)amineDipropylenetriamine56-18-83,3'-Iminobispropylamine1,7-Diamino-4-azaheptane4-Azaheptane-1,7-diamine3,3'-Iminobis(propylamine)Aminobis(propylamine)Iminobis(propylamine)3,3-DiaminodipropylamineDipropylentriamin

Show more names

IBPA3,3'-IMINODIPROPYLAMINE3,3'-DiaminodipropylamineNSC 7773FENTAMINE IBPA-3-Aminopropyl

P 2 (hardener)Imino-bis(3-propylamine)N-3-Aminopropyl-1,3-diaminopropane1,3-Propanediamine, N-(3-aminopropyl)-N'-(3-aminopropyl)propane-1,3-diamineDipropylamine, 3,3'-diamino-Bis-(3-aminopropyl)amine1-Propanamine, 3,3'-iminobis-

Database identifiers

CAS: 56-18-8
PubChem CID: 5942
DTXSID: DTXSID0025440
ChEMBL: CHEMBL28743
ChEBI: CHEBI:16841
UNII: RN1144MGND
EC Number: 200-261-2
Nikkaji: J9.891D

Properties

Computed structural properties

XLogP: -1.4
Topological polar surface area: 64.1 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 3
Rotatable bonds: 6
Heavy atoms: 9
Formal charge: 0
Complexity: 41.6

Experimental & physicochemical properties

Chemical Classes · 2 items

Nitrogen Compounds -> Amines, Aliphatic

Corrosives

CosmeticsBuffering

SpringerMaterials PropertiesFusion temperature

Density · 2 items

0.9307 at 68 °F (NTP, 1992) - Less dense than water; will float

0.938 @25 °C

SolubilitySoluble (>=10 mg/ml) (NTP, 1992)

Flash Point175 °F (NTP, 1992)

Physicochemical properties

Melting point: 14 °C · −14 °C(lit.)
Boiling point: 151 °C50 · 151 °C50 mm Hg(lit.)
Density: 0.938 g/mL · 0.938 g/mL at 25 °C(lit.)
refractive index: 20 · n20/D 1.481(lit.)
Flash point: 245 °F · 245 °F
storage temp.: 2 · 2-8°C
Water Solubility: Completely miscible in water
solubility: Chloroform (Slightly), Methanol (Slightly)
form: clear liquid
pka: 1 · pK1:8.02(+2);pK2:9.70(+1);pK3:10.70(0) (30°C)
color: Colorless to Almost colorless
BRN: 1071254 · 1071254
Stability: Air and light sensitive. Combustible. Incompatible with oxidizing agents.
Cosmetics Ingredients Functions: BUFFERING
InChI: 1S/C6H17N3/c7-3-1-5-9-6-2-4-8/h9H,1-8H2
InChIKey: OTBHHUPVCYLGQO-UHFFFAOYSA-N
SMILES: NCCCNCCCN
LogP: -0.826 · -0.826 (est)
CAS DataBase Reference: 56 · 56-18-8(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances: IMINO-BIS-PROPYLAMINE
FDA 21 CFR: 176.18 · 176.180; 177.1200
EWG's Food Scores: 2 · 2-6
FDA UNII: 1144 MGND · RN1144MGND
EPA Substance Registry System: Norspermidine (56-18-8)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05,GHS06
Signal word: Danger
Hazard statements: 310 · H310+H330-H302-H314-H317
Precautionary statements: 501 · P501-P272-P270-P262-P260-P271-P264-P280-P284-P361+P364-P303+P361+P353-P333+P313-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P405
target organs: thymus
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: T+,C
Risk Statements: 22 · 22-24-26-35-43-68-48/20/21
Safety Statements: 26 · 26-28-36/37/39-45
RIDADR: 2269 · UN 2269
WGK Germany: 2 · 2
RTECS: 9450000 · JL9450000
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: III
HS Code: 29252900 · 29252900
Storage Class: 6.1 A · 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
Hazard Classifications: 1 InhalationAcute · Acute Tox. 1 InhalationAcute Tox. 3 DermalAcute Tox. 4 OralEye Dam. 1Muta. 2Skin Corr. 1ASkin Sens. 1ASTOT RE 2
REACH Registrations: Active
Limited Quantities: 5 L · 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P262, P264, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P330, P333+P317, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P284, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P320, P321, P330, P333+P317, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Hazard information

Regulatory Information · 5 items

Chemical: 1,3-Propanediamine, N1-(3-aminopropyl)-

1,3-Propanediamine, N1-(3-aminopropyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediamine, N1-(3-aminopropyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 20-01-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/10361

1,3-Propanediamine, N-(3-aminopropyl)-: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment

DOT LabelCorrosive

Fire Hazards · 2 items

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

· Combustible material: may burn but does not ignite readily.

Health Hazards · 2 items

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

· TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death.

Hazards Summary · 1 item

Corrosive to skin; [Quick CPC] Irritating and corrosive; Toxic by ingestion and inhalation; [NTP] A severe eye and moderate skin irritant; Causes dyspnea and cyanosis in lethal-concentration studies of rats; [RTECS] Causes burns; May cause skin sensitization; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; Dermal LD50 (rat) between 200 and 400 mg/kg; [Alfa Aesar MSDS]

Safety & protection

Fire FightingExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Accidental Release Measures · 2 items

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 2 items

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).

Nonfire Spill ResponseExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Isolation and Evacuation · 2 items

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Immediate precautionary measure

Toxicology

Adverse EffectsDermatotoxin - Skin burns.

Toxicity DataLC50 (rat) = 30 mg/m3/4hr

Safety data

PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: 2
tsca: TSCA listed
rtecs: JL9450000
ridadr: UN 2269
hs_code: 29252900
risk_code: 22-24-26-35-43-68-48/20/21
Signal word: Danger
Symbol(GHS): GHS05,GHS06
hazard_code: T+,C
safety_code: 26-28-36/37/39-45
hazard_class: 8
Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
packing_group: III
target organs: thymus
Hazard statements: H310+H330-H302-H314-H317
Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
REACH Registrations: Active
Hazard Classifications: Acute Tox. 1 InhalationAcute Tox. 3 DermalAcute Tox. 4 OralEye Dam. 1Muta. 2Skin Corr. 1ASkin Sens. 1ASTOT RE 2
Precautionary statements: P501-P272-P270-P262-P260-P271-P264-P280-P284-P361+P364-P303+P361+P353-P333+P313-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P405

Chemistry & industry

Uses & manufacturing

UsesUsed as an intermediate for soaps, dyestuffs, rubber chemicals, emulsifying agents, petroleum specialties, insecticides, and pharmaceuticals; [NTP]

U.S. Production2023: <75,000 lb

Industry UsesIntermediate

Use ClassificationCosmetics -> Buffering

General Manufacturing Information · 2 items

All Other Basic Organic Chemical Manufacturing

1,3-Propanediamine, N1-(3-aminopropyl)-: ACTIVE

Applications · 3 items

UsesA structural homologue of the natural polyamine spermidine with antitumor activity that may make it useful as a antineoplastic agent.

UsesBis(3-aminopropyl)amine (BAPA) can be used:To synthesize chitosan based hydrogels having potential biomedical applications.For the functionalization of nanoparticles to yield terminal NH2 groups for further modifications. As an internal dispersing agent for the synthesis of water-dispersible polyurethanes.As a ligand in the preparation of [Cu(bapa)]2[Mo(CN)8]·7H2O photomagnetic coordination polymer.

General DescriptionA colorless liquid. Less dense than water. Flash point of 170°F. Very irritating to skin and eyes, and may be toxic by ingestion. Used to make soaps, dyes, and pharmaceuticals.

Upstream & downstream products

Upstream raw materials

1-Propanol N-(3-aminopropyl)-N'-[3-[(3-aminopropyl)amino]propyl]propane-1,3-diamine 1,3-Diaminopropane

Downstream products

1,9-BIS-BOC-1,5,9-TRIAZANONANE N,N'-BIS(3-AMINOPROPYL)-1,3-PROPANEDIAMINE

Suppliers84 total

湖北蝶化新材料科技有限公司86-18372897-544 18995560451

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海比阳实业有限公司+86-21-52699951; +8613917686115 · [email protected]

温州共赢化学有限公司+86-0086-577-64498589 +86-15355981851 · [email protected]

江苏星科元信息科技有限公司400-605-7200 15335295587

Additional notes

DefinitionChEBI: Bis(3-aminopropyl)amine is a polyazaalkane. It has a role as an algal metabolite and a plant metabolite. It is a conjugate base of a bis(3-azaniumylpropyl)azanium.