Tenidap

HCID 60712CAS 120210-48-2
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Basic information

Standard SMILES
NC(=O)n1c(O)c(C(=O)c2cccs2)c2cc(Cl)ccc21
InChIKey
IZSFDUMVCVVWKW-UHFFFAOYSA-N
Molecular formula
C14H9ClN2O3S
Average molar mass
320.8 g/mol
Monoisotopic mass
320.00224083

Overview

Tenidap is a member of indoles, a member of thiophenes, an organochlorine compound and a member of ureas. It has a role as a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor.

Names & identifiers

Preferred name
Tenidap
IUPAC
5-chloro-2-hydroxy-3-(thiophene-2-carbonyl)indole-1-carboxamide
English name
Tenidap
Molecular formula
C14H9ClN2O3S
Molecular weight
320.75

Names & synonyms

TENIDAP120210-48-2CP-66248DTXSID9046104CP-66,248(Z)-5-Chloro-3-(alpha-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide9K7CJ74ONHCP 66248CHEMBL1097558CHEBI:358475-chloro-2-hydroxy-3-(thiophene-2-carbonyl)-1H-indole-1-carboxamideNCGC00160352-01
Show more names
AKOS 91367TENIDAP USP/EP/BPCP66248,CP-66248-25-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide(3Z)-5-CHLORO-3-[HYDROXY(2-THIENYL)METHYLENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-1-CARBOXAMIDE1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)-
5-chloro-2-hydroxy-3-(thiophene-2-carbonyl)indole-1-carboxamide(Z)-5-chloro-3-(hydroxy(thiophen-2-yl)methylene)-2-oxoindoline-1-carboxamide1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (Z)-DTXCID7026104TenidapumTenidapum [INN-Latin](3Z)-5-chloro-3-[hydroxy(2-thienyl)methylene]-2-oxo-indoline-1-carboxamide(3Z)-5-chloro-3-[hydroxy(2-thienyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-1-carboxamide

Database identifiers

CAS
120210-48-2
PubChem CID
60712
DTXSID
DTXSID9046104
ChEMBL
CHEMBL1097558
ChEBI
CHEBI:35847
UNII
9K7CJ74ONH
Nikkaji
J3.110.323A、J328.807B、J594.228D、J717.958H

Properties

Computed structural properties

XLogP
3.8
Topological polar surface area
114 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
4
Rotatable bonds
2
Heavy atoms
21

Physicochemical properties

Melting point
230 ° · 230° (dec)
Boiling point
538.1 · 538.1±60.0 °C(Predicted)
Density
1.648 · 1.648±0.06 g/cm3(Predicted)
storage temp.
4 °C · Store at +4°C
solubility
1 mg/mL, · DMSO: soluble1mg/mL, clear (warmed)
form
powder

Safety & regulation

Safety data

wgk
3
risk_code
22
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xn
Storage Class
11 - Combustible Solids

Chemistry & industry

Applications · 2 items

UsesAnti-inflammatory (osteoarthritis and rheumatoid arthritis).

UsesTenidap is one of the nonsteroidal antiinflammatory drugs (NSAIDs). Tenidap is an NSAID that preferentially inhibits COX-1. Tenidap inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes.

Upstream & downstream products

Suppliers34 total

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]
Sinoway Industrial co., ltd.+86-0592-5800732 +86-13806035118 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]

Additional notes

DefinitionChEBI: Tenidap is a member of indoles, a member of ureas, a member of thiophenes and an organochlorine compound. It has a role as a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor.

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