Tobramycin Sulphate Salt

HCID 62005CAS 49842-07-1

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Basic information

Standard SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O.O=S(=O)(O)O
InChIKey: ZEUUPKVZFKBXPW-TWDWGCDDSA-N
Molecular formula: C18H39N5O13S
Average molar mass: 565.6 g/mol

Overview

Tobramycin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.

Names & identifiers

Preferred name: Tobramycin Sulphate Salt
IUPAC: (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;sulfuric acid
English name: Tobramycin sulphate
Molecular formula: C18H39N5O13S
Molecular weight: 565.59

Names & synonyms

Tobramycin Sulphate SaltMLS000069826MFCD00133864SMR000058891Tobramycin (sulfate)C18H39N5O13S(2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;sulfuric acidTobramycin Sulfate Salt; O-3-amino-3-deoxy-a-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(1?4)]-2-deoxy-D-streptamine Sulfate (5:2)Tobramycin Impurity 4Opera_ID_1050SCHEMBL2837Nebramycin Factor 6 (sulfate);Deoxykanamycin B (sulfate)

Show more names

Tobramycin sulfateTOBRAMYCIN SULPHATEobracinetenemicinTOBRAMYCIN SLIPHATETOBRAMYCIN SULPHATETobraMycin Sulfate API1-epitobramycinsulfateTOBRAMYCIN SULFATE SALTTobramycin Monosulphate Salt

126777-32-0CHEMBL1200780HMS2230J04EBC-98152AKOS025310614(2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol SulfateNS00089156Tobramycin sulfate salt, aminoglycoside antibiotic

Database identifiers

CAS: 49842-07-1
PubChem CID: 62005
ChEMBL: CHEMBL1200780

Properties

Computed structural properties

Topological polar surface area: 351 Å²
Hydrogen bond donors: 12
Hydrogen bond acceptors: 18
Rotatable bonds: 6
Heavy atoms: 37
Formal charge: 0
Complexity: 690

Physicochemical properties

storage temp.: 2 · 2-8°C
solubility: Methanol (Slightly), Water (Sparingly)
form: Powder
color: White to off-white
Water Solubility: Soluble in water (50 mg/ml).
Stability: Hygroscopic
InChIKey: ZEUUPKVZFKBXPW-SYOBZNKXNA-N
SMILES: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
CAS DataBase Reference: 49842 · 49842-07-1
FDA UNII: 0 RXD7JK · HJT0RXD7JK
Proposition 65 List: Tobramycin Sulfate
NCI Drug Dictionary: tobramycin sulfate
EPA Substance Registry System: Tobramycin sulfate (49842-07-1)
UNSPSC Code: 51281677 · 51281677
NACRES: 85 · NA.85
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 302 · H302-H315-H319-H335
Precautionary statements: 261 · P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c
PPE: 3 · Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes: T
Risk Statements: 61 · 61-20/21/22
Safety Statements: 53 · 53-22-36/37/39-45
WGK Germany: 3 · 3
HS Code: 2941900000 · 2941900000
Storage Class: 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard Classifications: 4 DermalAcute · Acute Tox. 4 DermalAcute Tox. 4 InhalationRepr. 1B

Safety & regulation

Safety data

PPE: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
wgk: 3
hs_code: 2941900000
risk_code: 61-20/21/22
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: T
safety_code: 53-22-36/37/39-45
Storage Class: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Hazard statements: H302-H315-H319-H335
Hazard Classifications: Acute Tox. 4 DermalAcute Tox. 4 InhalationRepr. 1B
Precautionary statements: P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c

Chemistry & industry

Applications · 2 items

UsesNebcin (Lilly).

UsesTobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.