Tobramycin Sulphate Salt → Tobramycin

HRID 326523

Reaction equation

HRID 326523 reaction equation
[CH2:1]1[C@@H:6]([NH2:7])[C@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:17])[C@H:11]([NH2:18])[C@H:10]2[OH:19])[C@@H:4]([OH:20])[C@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][NH2:29])[C@@H:25]([OH:30])[CH2:24][C@H:23]2[NH2:31])[C@H:2]1[NH2:32].OS(O)(=O)=O>O>[CH2:1]1[C@@H:6]([NH2:7])[C@H:5]([O:8][C@H:9]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:17])[C@H:11]([NH2:18])[C@H:10]2[OH:19])[C@@H:4]([OH:20])[C@H:3]([O:21][C@H:22]2[O:27][C@H:26]([CH2:28][NH2:29])[C@@H:25]([OH:30])[CH2:24][C@H:23]2[NH2:31])[C@H:2]1[NH2:32]

Participants

3

Reactant 1

HCID 62005Tobramycin Sulphate Salt

Product 1

HCID 36294Tobramycin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Foam wound materials containing tobramycin sulfate were prepared as shown in Example 1. Once the materials were placed onto grid supports they were maintained at room temperature and covered with a foil wrap. Every 12 hours for nine days, 5 ml of water was applied onto the foam bandage materials and eluent was collected. Two ml samples containing SDMC-entrapped tobramycin were assayed for tobramycin antibiotic activity using standard antimicrobial assays. The results are shown in Table IX.

Workup

  1. customwere prepared
  2. customwas collected
  3. additionTwo ml samples containing SDMC-entrapped tobramycin

Sources & evidence

ORD record
ord-c938fb36e94549409128815a37398402
Source dataset
uspto-grants-1993_12
Patent number
US05269979

Linked notes

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