Basic information
- CAS
7446-26-6- Standard SMILES
O=P([O-])([O-])OP(=O)([O-])[O-].[Zn+2].[Zn+2]- InChIKey
OMSYGYSPFZQFFP-UHFFFAOYSA-J- Molecular formula
- O7P2Zn2
- Average molar mass
- 304.7 g/mol
- Monoisotopic mass
- 301.77021
Overview
Zinc pyrophosphate is a phosphate of zinc. Zinc is a metallic element with the atomic number 30. It is found in nature most often as the mineral sphalerite. Though excess zinc in harmful, in smaller amounts it is an essential element for life, as it is a cofactor for over 300 enzymes and is found in just as many transcription factors. (L48, L49)
Names & identifiers
- Preferred name
- Zinc pyrophosphate
- IUPAC
- dizinc;phosphonato phosphate
- English name
- ZINC PYROPHOSPHATE
- Molecular formula
- H4O7P2Zn
- Molecular weight
- 243.35
Names & synonyms
Zinc pyrophosphateDizinc pyrophosphateDiphosphoric acid, zinc salt (1:2)UNII-6ERT96A6216ERT96A621EINECS 231-203-4ZINC PYROPHOSPHATE [MI]DTXSID0064705Zinc pyrophosphic acidRefChem:196066KLENPHOS 300Zn2P2O7
Show more names
ZincpyrophosphatZINC DIPHOSPHATEZinc DiiphosphateDizinkpyrophosphatdizincpyrophosphateDiphosphoricacid,zincsalt(1:2)Diphosphoric acid α,α:β,β-dizinc salt
DTXCID4047670dizinc(2+) ion (phosphonatooxy)phosphonate7446-26-6dizinc;phosphonato phosphatedizinc diphosphateSCHEMBL60092NS00081875Q3560487
Database identifiers
- CAS
7446-26-6- PubChem CID
- 62641
- DTXSID
DTXSID0064705- UNII
- 6ERT96A621
- EC Number
- 231-203-4
- Nikkaji
- J138.611E
Properties
Computed structural properties
- Topological polar surface area
- 136 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 0
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 124
Experimental & physicochemical properties
Chemical ClassesMetals -> Phosphates, Metallic Salts
Physical DescriptionWhite solid; [Merck Index] 30-50% Aqueous solution: Slightly viscous odorless liquid; [Klenzoid MSDS]
Physicochemical properties
- Density
- 23 · d23 3.75
- solubility
- 2 O; · insoluble in H2O; soluble in dilute acid solutions
- form
- white crystalline powder
- color
- white crystals, crystalline powder
- Water Solubility
- 2 O; · insoluble H2O; soluble dilute mineral acids [MER06]
- InChI
- InChI=1S/H4O7P2.Zn/c1-8(2,3)7-9(4,5)6;/h(H2,1,2,3)(H2,4,5,6);
- InChIKey
- MZAGDLUUYJDJTE-UHFFFAOYSA-N
- SMILES
- O(P(O)(O)=O)P(O)(O)=O.[Zn]
- FDA UNII
- 6 ERT96A621 · 6ERT96A621
- EPA Substance Registry System
- Dizinc pyrophosphate (7446-26-6)
- Symbol(GHS)
- 9 · GHS09
- Signal word
- Warning
- Hazard statements
- 410 · H410
- Precautionary statements
- 273 · P273-P391-P501
- TSCA
- TSCA listed
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
Warning
H400 (95.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
P273, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 70 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Not Classified
Hazard information
Regulatory Information
Chemical: Diphosphoric acid, zinc salt (1:2)
Status: Active Update: 06-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24543
Diphosphoric acid, zinc salt (1:2): Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryAn eye irritant; [Klenzoid MSDS] See Zinc. See Disodium pyrophosphate.
Hazard Classes and CategoriesAquatic Acute 1 (95.7%)
Safety & protection
Exposure Control and Personal Protection0.1 [mg/m3] (respirable fraction), 2 mg/m3 (inhalable fraction) for Zn inorg. cmpnds[German Research Foundation (DFG)]
Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (L134)
Chronic Oral: 0.3 mg/kg/day (L134)
Toxicology
TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)
Health EffectsChronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)
Exposure RoutesInhalation (L49) ; oral (L49) ; dermal (L49)
Toxicity Summary
Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)
Signs and Symptoms
Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Safety data
- tsca
- TSCA listed
- Signal word
- Warning
- Symbol(GHS)
- GHS09
- Hazard statements
- H410
- REACH Registrations
- Active
- Precautionary statements
- P273-P391-P501
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)
Uses & manufacturing
UsesUsed as a drinking water additive; [Klenzoid MSDS] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]
General Manufacturing InformationDiphosphoric acid, zinc salt (1:2): ACTIVE
Applications
UsesPigment
Suppliers31 total
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
湖北成丰化工有限公司13125175253 · [email protected]
普善实业（陕西）有限公司029-81310890 18165209495 · [email protected]
苏州市森菲达化工有限公司18796480002 18796480002 · [email protected]
广东方信生物科技有限公司0751-2838688 13376594225 · [email protected]
湖北广奥生物科技有限公司027-02702759223056 18162699093 · [email protected]
湖北成海化工有限公司027-59220433 18327245847 · [email protected]
广东翁江化学试剂有限公司0751-2815987 13927875076 · [email protected]
湖北世腾化工科技有限公司18971850150 19086915685 · [email protected]
北京华威锐科化工科技有限公司89508211 18501085097 · [email protected]
湖北齐飞医药化工有限公司027-59322506 18071128681 · [email protected]
安泰精细化工技术有限公司18503026267 · [email protected]
金锦乐(湖南)化学有限公司18001959627(微信同号) 18001959627 · [email protected]
Shaanxi Dideu New Materials Co. Ltd18192503167 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
湖北摆渡化学有限公司027-59106051 13627137652 · [email protected]
湖北信康医药化工有限公司027-027-59308705 18871579363 · [email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
郑州艾克姆化工有限公司13303867194 · [email protected]
湖北拓邦化工有限公司027-59106185 13986192185 · [email protected]
SUZHOU SENFEIDA CHEMICAL CO.,LTD+86-0512-83500002 +86-15195660023 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 17389186172 · [email protected]
湖北奕化新材料科技有限公司17754433341 18086038039
广州安纳医药科技有限公司020-86211473 13925088720 · [email protected]
湖北成丰化工有限公司15827338311 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
武汉斯麦克生物科技有限公司18186154374 · [email protected]
天门恒昌化工有限公司027-59322316 15172518801 · [email protected]
湖北鑫红利化工有限公司027-027-59106151 15172325309 · [email protected]
Related reactions
2 records
Compound notes
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