Ciprofloxacin Hydrochloride Anhydrous

HCID 62999

Basic information

CAS
86483-48-9
Standard SMILES
Cl.O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O
InChIKey
DIOIOSKKIYDRIQ-UHFFFAOYSA-N
Molecular formula
C17H19ClFN3O3
Average molar mass
367.8 g/mol
Monoisotopic mass
367.1098973

Names & identifiers

Preferred name
Ciprofloxacin Hydrochloride Anhydrous
IUPAC
1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
English name
Ciprofloxacin hydrochloride
Molecular formula
C17H18FN3O3.xHCl
Molecular weight
367.81

Names & synonyms

93107-08-5Ciprofloxacin Hydrochloride Anhydrous0MP32MFP6CRefChem:91867286483-48-91-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid xhydrochloride1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochlorideCiprofloxacin monohydrochlorideCHEBI:310388Bay o 9867Ciprofloxacin (monohydrochloride)
Show more names
CIPROFLOXACIN HYDROCHLORIDE MONOHYDRATECiprofloxacin base/HCLCifloxCiprofloxacin Impurity 14CIPROFLOXACIN HCL HYDRATECIPROFLOXACIN HCL (ANHYDROUS)Enrofloxacin nicotinate USP/EP/BP
BAY-O-9867CiproxanCiproxinciprofloxacin hydrochloride (anhydrous)BAY-o 98671-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochlorideciprofloxacine hydrochloridePrestwick_67

Database identifiers

CAS
86483-48-9、93107-08-5
PubChem CID
62999
DTXSID
DTXSID1047788
ChEBI
CHEBI:310388
UNII
0MP32MFP6C
EC Number
642-985-5

Properties

Computed structural properties

Topological polar surface area
72.9 Ų
Hydrogen bond donors
3
Hydrogen bond acceptors
7
Rotatable bonds
3
Heavy atoms
25

Physicochemical properties

Melting point
300 °C · >300 °C
storage temp.
Inert atmosphere,Room Temperature
solubility
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form
Solid
color
White to Off-White
BCS Class
3 · 3/1

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation];H317 (66.7%): May cause an allergic skin reaction [Warning Sensitization, Skin];H319 (66.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H334 (66.7%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory];H335 (33.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H400 (33.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard];H410 (66.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P233, P260, P261, P264, P264+P265, P271, P272, P273, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 3 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (33.3%);Skin Sens. 1 (66.7%);Eye Irrit. 2 (66.7%);Resp. Sens. 1 (66.7%);STOT SE 3 (33.3%);Aquatic Acute 1 (33.3%);Aquatic Chronic 1 (66.7%)

Safety data

hs_code
29419000
risk_code
36/37/38
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xi
safety_code
26-36

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 3 items

Substances that inhibit the growth or reproduction of BACTERIA.

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II.

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 CYP1A2.

Applications · 2 items

UsesCiprofloxacin hydrochloride, C17H18FN3O3 •HCl•H2O, is a synthetic broad-spectrum antibacterial agent. Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. it was the drug of choice forcombating anthrax. Ciprofloxacin hydrochloride (Cipro, 500-mg tablets) is highly active against the important bacterial causes of enteritis, including diarrheogenic Escherichia coli, Vibrio cholerae, Salmonella species, Shigella species, Campylobacter jejuni, Aeromonas species, and Yersinia enterocolitica.

UsesCiprofloxacin Hydrochloride Monohydrate is a fluorinated quinolone antibacterial.

Suppliers100 total

北京华美互利生物化工010-56205725 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
深圳市健竹科技有限公司0755-89218110 13480856786
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

Additional notes

DefinitionChEBI: The anhydrous form of the monohydrochloride salt of ciprofloxacin.

Related reactions

5 records

Compound notes

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