Ciprofloxacin → Ciprofloxacin Hydrochloride Anhydrous

HRID 256791

Reaction equation

HRID 256791 reaction equation
[CH:1]1[C:2]2[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]([CH:22]3[CH2:24][CH2:23]3)[C:3]=2[CH:4]=[C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:6]=1[F:7].[Na+].[Cl-:26]>O>[CH:1]1[C:2]2[C:17](=[O:18])[C:16]([C:19]([OH:21])=[O:20])=[CH:15][N:14]([CH:22]3[CH2:23][CH2:24]3)[C:3]=2[CH:4]=[C:5]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[C:6]=1[F:7].[ClH:26]

Participants

4

Reactant 2

HCID 2764Ciprofloxacin4×HCID 5234Sodium Chloride

Product 1

HCID 62999Ciprofloxacin Hydrochloride Anhydrous

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To demonstrate the release of the ciprofloxacin from the cryogel in a simulated body fluid environment, the cryogel/ciprofloxacin disk was immersed in 1.0 ml portions of 0.9% NaCl in distilled water for 1 hour, after which the procedure was repeated. HPLC analyses of the saline extracts for ciprofloxacin were made. The pH of these saline extracts was found to be 5.5. The initial content of ciprofloxacin in the disk was estimated to be 15 mg. The results are shown in Table 9.

Sources & evidence

ORD record
ord-3f95ac133b10414584ef19a16ad6cbad
Source dataset
uspto-grants-1993_11
Patent number
US05260066

Linked notes

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