Zinc pyrithione
ZPT · Pyrithione zinc · ZNPT · 1-HYDROXYPYRIDINE-2-THIONE ZINC · Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt · zincomadine · 2-MERCAPTOPYRIDINE N-OXIDE ZINC SALT · 1-HYDROXYPYRIDINE-2-THIONE ZINC SALT
Identifiers & Physical Properties
| CAS No. | 13463-41-7 |
|---|---|
| Molecular formula | C10H8N2O2S2Zn |
| Average molar mass | 317.71 g/mol |
| SMILES | O[N+]1=CC=CCC1=S.On1ccccc1=S.[Zn] |
| PubChem CID | 6327770 |
Chemical & Physical Properties
| Melting point | approximate 240℃ |
|---|---|
| Density | 1.782 g/cm3(Temp: 25 °C) |
| Vapor pressure | 0Pa at 25℃ |
| Storage conditions | Sealed in dry,Room Temperature |
| Solubility | almost transparency in PyridineInsoluble (<0.1 g/100 mL at 21 ºC) |
| Physical state | Powder |
| Color | White to Orange to Green |
| Odor | Mild Characteristic |
| Merck | 14,7994 |
| Cosmetics Ingredients Functions | PRESERVATIVEHAIR CONDITIONINGANTI-SEBORRHEICANTI-SEBUM |
| InChI | InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8/h2*1-4,8H/q+2/p-2 |
| InChIKey | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
| SMILES | C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-] |
| LogP (partition coefficient) | 0.9 at 25℃ and pH7.5-7.7 |
| Surface tension | 73mN/m at 7.22mg/L and 20℃ |
| CAS DataBase Reference | 13463-41-7(CAS DataBase Reference) |
| EWG's Food Scores | 2-3 |
| FDA UNII | R953O2RHZ5 |
| ATC code | D11AX12 |
| EPA Substance Registry System | Zinc pyrithione (13463-41-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
| GHS pictogram | GHS05,GHS06,GHS08,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H301-H318-H330-H360D-H372-H410 |
| GHS precautionary statements | P202-P260-P273-P280-P304+P340+P310-P305+P351+P338 |
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard symbols | T+,N,T |
| Risk statements (R) | 24/25-26-37/38-41-50/53-23-22 |
| Safety statements (S) | 26-28-36/37/39-45-61-60-39 |
| UN transport number | UN 2811 6.1/PG 2 |
| Water hazard class (WGK) | 3 |
| RTECS number | ZH0950000 |
| TSCA inventory status | TSCA listed |
| Hazard class | 6.1(b)Acute Tox. 2 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1Eye Dam. 1Repr. 1BSTOT RE 1 |
| Packing group | III |
| Customs code | 29333990 |
| Storage class | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Hazardous substances data | 13463-41-7(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: 177mg/kg |
| REACH registrations | Active |
Safety & Regulations
| Personal protective equipment (PPE) | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK) | 3 |
| TSCA inventory status | TSCA listed |
| RTECS number | ZH0950000 |
| UN transport number | UN 2811 6.1/PG 2 |
| Customs code | 29333990 |
| Toxicity | LD50 oral in rat: 177mg/kg |
| Risk statements (R) | 24/25-26-37/38-41-50/53-23-22 |
| Signal word | Danger |
| GHS pictogram | GHS05,GHS06,GHS08,GHS09 |
| Hazard symbols | T+,N,T |
| Safety statements (S) | 26-28-36/37/39-45-61-60-39 |
| Hazard class | 6.1(b)Acute Tox. 2 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1Eye Dam. 1Repr. 1BSTOT RE 1 |
| Storage class | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| Packing group | III |
| GHS hazard statements | H301-H318-H330-H360D-H372-H410 |
| REACH registrations | Active |
| GHS precautionary statements | P202-P260-P273-P280-P304+P340+P310-P305+P351+P338 |
| Hazardous substances data | 13463-41-7(Hazardous Substances Data) |
Applications & Uses
Uses
Shampoo for dandruff,zinc pyrithione can inhibit Gram positive and negative bacteria and mold growth,Care hair Effectively , delay hair aging ,control white hair and hair loss generation. zinc pyrithion is also used as a cosmetic preservative, oil, paint biocide. Zinc pyrithione has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus,playing a role in dandruff .
Description
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
Uses
zinc pyrithione is a preservative against bacteria, fungi, and yeast. It is unstable in light and in the presence of oxidizing agents. Zinc pyrithione is useful in gels, creams, heavy lotions, and talcum powder.
Uses
Reactions may lead to photosensitive eczema and actinic reticuloid syndrome. Zinc pyrithione is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.
Uses
Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks. Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
General Description
Fine beige granules.