4-Hydroxybenzamide (HCID 65052)

Overview

P-Hydroxybenzamide is a member of benzamides.

Names & identifiers

Preferred name: 4-Hydroxybenzamide
IUPAC: 4-hydroxybenzamide
English name: 4-Hydroxybenzamide
Molecular formula: C7H7NO2
Molecular weight: 137.14

Names & synonyms

4-Hydroxybenzamide619-57-8p-HydroxybenzamideBenzamide, 4-hydroxy-9OU5YD093JDTXSID10210931NSC-524134RefChem:99273DTXCID40133422210-602-74-Hydroxy-benzamideMFCD00007997

Show more names

Benzamide,p-hydroxy-Benzamide,4-hydroxy-4-Hydroxybenzamide>4-HYDROXYBENZAMIDE 98%Tetracaine Impurity 474-HYDROXYBENZAMIDE, 97+%4-Hydroxybenzamide, 98+%4-Hydroxy-benzoesaeure-amid

41911-58-44-hydroxybenzene carboxamideCHEMBL123617P-HYDROXYBENZOIC ACID AMIDEBDBM50106201SY016463H0200EN300-18541

Database identifiers

CAS: 619-57-8
PubChem CID: 65052
DTXSID: DTXSID10210931
ChEMBL: CHEMBL123617
ChEBI: CHEBI:220253
UNII: 9OU5YD093J
EC Number: 210-602-7
Nikkaji: J94.905A

Properties

Computed structural properties

XLogP: 0.3
Topological polar surface area: 63.3 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 1
Heavy atoms: 10
Formal charge: 0
Complexity: 128

Experimental & physicochemical properties

SpringerMaterials PropertiesChemical shift

LogP0.33

Endocrine DisruptorsPotential endocrine disrupting compound

Physicochemical properties

Melting point: 161 · 161-162 °C (lit.)
Boiling point: 345.3 · 345.3±25.0 °C(Predicted)
Density: 1.286 · 1.286±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 8.6 · 8.60±0.13(Predicted)
color: White to Light yellow to Dark green
BRN: 1906921 · 1906921
InChI: InChI=1S/C7H7NO2/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
InChIKey: QXSAKPUBHTZHKW-UHFFFAOYSA-N
SMILES: C(N)(=O)C1=CC=C(O)C=C1
CAS DataBase Reference: 619 · 619-57-8(CAS DataBase Reference)
FDA UNII: 9 OU5YD093J · 9OU5YD093J
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs: Respiratory system
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-37/39-36
WGK Germany: 3 · 3
HazardClass: IRRITANT
HS Code: 29242990 · 29242990
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 11.3% (6 of 53) of reports.

Warning

H315 (88.7%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 53 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesSkin Irrit. 2 (88.7%)

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
hs_code: 29242990
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-37/39-36
hazard_class: IRRITANT
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H315-H319-H335
Hazard Classifications: Eye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Chemistry & industry

Applications · 3 items

Uses4-Hydroxybenzamide is a secondary metabolite from marine sponge Phakellia fusca.

Uses4-Hydroxybenzamide was used in the synthesis of balanol, a potent protein kinase C (PKC) inhibitor.

General DescriptionThe standard molar enthalpy of formation of 4-hydroxybenzamide was studied by micro- or macrocombustion calorimetry.

Upstream & downstream products

Downstream products

4-Hydroxythiobenzamide

Suppliers50 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

荟达医药科技(上海)有限公司15173502222 · [email protected]

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

郑州汇聚化工有限公司13393710386 · [email protected]

Additional notes · 1 item

Definition4-Hydroxybenzamide (4HBM) is an important biological active compound that has the presence of various biological activities such as antimycobacterial, antifungal, antimicrobial, herbicidal, and antioxidant. The benzamide derivatives are also used in medical, pharmaceutical, and therapeutic applications because of their anti-inflammatory, antibacterial, and antifungal activities. The amine and carboxylic acids are important functional groups of present molecules. These are mainly utilized in the field of chemical industry. The cocrystallization of itraconazole (a very slightly soluble triazole antifungal drug) with 4-hydroxybenzamide (4OHBZA) can potentially increase the drug solubility at pH1.2 and 37 °C by 64 times[1-2].