Potassium Carbonate → 4-Aminocarbonylphenoxyacetic acid methylester
Reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.Br[CH2:12][C:13]([O:15][CH3:16])=[O:14].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[CH3:16][O:15][C:13](=[O:14])[CH2:12][O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1Participants
6
Procedure
A mixture of p-hydroxybenzamide (3.43 g), methyl bromoacetate (2.37 ml) and K2CO3 (3.45 g) was stirred for 12 hr in 25 ml of DMF. The reaction mixture was diluted with water (150 ml); the solid was filtered, washed with water, and air dried. Crystallization from ethanol gave 3.3 g (63%) of the title compound as white crystals.
Workup
- filtrationthe solid was filtered
- washwashed with water, and air
- customdried
- customCrystallization from ethanol
Sources & evidence
- ORD record
- ord-660078129add4fc29c165ea2d40c339c
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05414132
Reaction notes
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