Betamethasone Sodium Phosphate

HCID 65478
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Basic information

CAS
151-73-5
Standard SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)([O-])[O-].[Na+].[Na+]
InChIKey
PLCQGRYPOISRTQ-LWCNAHDDSA-L
Molecular formula
C22H28FNa2O8P
Average molar mass
516.4 g/mol
Monoisotopic mass
516.13012157

Names & identifiers

Preferred name
Betamethasone Sodium Phosphate
IUPAC
disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
English name
Betamethasone 21-phosphate disodium
Molecular formula
C22H28FNa2O8P
Molecular weight
516.4

Names & synonyms

151-73-5Betamethasone sodium phosphateBetamethasone disodium phosphateBetamethasone 21-disodium phosphateBetamethasone 21-phosphate disodiumBetamethasone 21-phosphate disodium saltBetamethazone disodium phosphateDTXSID80471377BK02SCL3W9-Fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate)NSC-90616CHEBI:3078
Show more names
DurabetasonbetnesolbentelanCelestanBentalanNSC 90616Vista-Methasone
DTXCID6027137Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11beta,16beta)-betamethason sodium phosphateVistamethasoneBetam-ophtalVistamethasone nNSC90616RefChem:54528

Database identifiers

CAS
151-73-5
PubChem CID
65478
DTXSID
DTXSID8047137
ChEMBL
CHEMBL1200762
ChEBI
CHEBI:3078
UNII
7BK02SCL3W
EC Number
205-797-0
Nikkaji
J7.409H

Properties

Computed structural properties

Topological polar surface area
147 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
9
Rotatable bonds
3
Heavy atoms
34

Physicochemical properties

Melting point
206 · 206-211°C
alpha
98 · +98.0~+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)
storage temp.
room temp
solubility
Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form
Solid
color
White to Off-White

Safety & regulation

GHS classification

GHS Classification · 5 items

Danger

H302 (44.2%): Harmful if swallowed [Warning Acute toxicity, oral]；H330 (54.9%): Fatal if inhaled [Danger Acute toxicity, inhalation]；H360 (42.5%): May damage fertility or the unborn child [Danger Reproductive toxicity]；H360D (15%): May damage the unborn child [Danger Reproductive toxicity]；H372 (48.7%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]；H373 (12.4%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]；H410 (46.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P203, P260, P264, P270, P271, P273, P280, P284, P301+P317, P304+P340, P316, P318, P319, P320, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 113 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety Information · 1 item

IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Environment tier I assessment；IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-: Human health tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (44.2%)；Acute Tox. 2 (54.9%)；Repr. 1B (42.5%)；Repr. 1B (15%)；STOT RE 1 (48.7%)；STOT RE 2 (12.4%)；Aquatic Chronic 1 (46.9%)

Regulatory information

Regulatory InformationBetamethasone sodium phosphate: Does not have an individual approval but may be used under an appropriate group standard

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
rtecs
TU4056500
hs_code
29372290
Toxicity
LD50 orl-rat: 1877 mg/kg DRUGAY -,1075,90
risk_code
22

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 1 item

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Uses & manufacturing

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Applications · 2 items

UsesNasal, Ophthalmic, Oral, Parenteral

UsesBetamethasone 21-Phosphate Disodium Salt (Dexamethasone Sodium Phosphate EP Impurity B) is a Betamethasone derivative. It is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties which can be used in treatment of asthma and itching.

Suppliers100 total

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]

Additional notes

DefinitionChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

Related reactions

2 records
New reaction record

Compound notes

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