Betamethasone → Cortisone

HRID 1885569

Reaction equation

HRID 1885569 reaction equation
C[C@@H:2]1[C@:19]([OH:28])([C:20]([CH2:22][O:23]P([O-])([O-])=O)=[O:21])[C@:18]2([CH3:29])[C@H:4]([C@H:5]3[C@:15](F)([C@@H:16]([OH:30])[CH2:17]2)[C@:14]2([CH3:32])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[CH2:7][CH2:6]3)[CH2:3]1.[Na+].[Na+].C[C@@H]1[C@](O)(C(CO)=O)[C@]2(C)[C@H]([C@H]3[C@](F)([C@@H](O)C2)[C@]2(C)C(=CC(C=C2)=O)CC3)C1>>[CH3:32][C@@:14]12[C@H:15]3[C:16]([CH2:17][C@:18]4([CH3:29])[C@@:19]([OH:28])([C:20]([CH2:22][OH:23])=[O:21])[CH2:2][CH2:3][C@H:4]4[C@@H:5]3[CH2:6][CH2:7][C:8]1=[CH:9][C:10](=[O:11])[CH2:12][CH2:13]2)=[O:30]

Participants

3

Reactant 2

HCID 9782BetamethasoneHCID 65478Betamethasone Sodium Phosphate

Product 1

HCID 222786Cortisone

Procedure

Eight rabbits of the New Zealand breed were used, weighing approximately 2 kg. In the right eye of each animal, 0.8 ml/week of Bentelan Depot (equivalent to 4 mg betametasone) were instilled for 4 weeks. The left eye was kept as control. The medicament, administered subconjunctivally, brought about an increase of the intraocular tension in the first week, reached its peak in the second week and then remained constant until the fifth week.

Workup

  1. temperaturean increase of the intraocular tension in the first week
  2. customremained constant until the fifth week

Sources & evidence

ORD record
ord-ed12391bc7ef41f78560f3533f2d9e73
Source dataset
uspto-grants-1992_09
Patent number
US05145871

Linked notes

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