Dimethylcarbamoyl Chloride

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

General First Aid:

(General first aid procedures)

PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U097, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... Summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/

For more Disposal Methods (Complete) data for DIMETHYLCARBAMOYL CHLORIDE (7 total), please visit the HSDB record page.

THE PROCESSES SHOULD ... TAKE PLACE IN WELL VENTILATED PREMISES UNDER A SLIGHT NEGATIVE PRESSURE TO AVOID ANY DIFFUSION OF POLLUTANTS. THE PROCESS PLANT SHOULD BE EQUIPPED WITH LOCAL EXHAUST DEVICES, IN PARTICULAR AT FLANGES, VALVES, ETC, WHERE LEAKS ARE MORE LIKELY TO ARISE.

PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/

For more Preventive Measures (Complete) data for DIMETHYLCARBAMOYL CHLORIDE (13 total), please visit the HSDB record page.

Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]:

Immediate precautionary measure

0.005 [ppm]

8 hr Time Weighted Average (TWA): 0.005 ppm, skin.

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.

A2; Suspected human carcinogen.

0.005 ppm [2006]

TERRESTRIAL FATE: If dimethylcarbamoyl chloride is released to soil, it will be expected to rapidly hydrolyze if the soil is moist, based upon a half-life of 54 sec at 14 °C(SRC) calculated from a measured hydrolysis rate constant(1). Since it rapidly hydrolyzes, adsorption to and volatilization from moist soil are not expected to be significant processes, although no data specifically regarding the fate of dimethylcarbamoyl chloride in soil were located(SRC). The potential for volatilization of dimethylcarbamoyl chloride from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.95 mm Hg(2). Biodegradation should not be an important process since hydrolysis is such a rapid process(SRC).

AQUATIC FATE: If dimethylcarbamoyl chloride is released to water, it will be expected to rapidly hydrolyze, based upon a half-life of 54 sec at 14 °C(SRC) calculated from a measured hydrolysis rate constant(1). The products of hydrolysis are dimethylamine, carbon dioxide, and hydrogen chloride(2). Since it rapidly hydrolyzes, bioconcentration, volatilization, and adsorption to sediment and suspended solids are not expected to be significant processes(SRC). No data were located concerning biodegradation, but dimethylcarbamoyl chloride probably abiotically degrades via hydrolysis significantly faster than via biodegradation(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dimethylcarbamoyl chloride, which has a vapor pressure of 1.95 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase dimethylcarbamoyl chloride is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 24 hours(SRC), calculated from its rate constant of 16X10-12 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). The hydrolysis half-life for dimethylcarbamoyl chloride is 54 sec(SRC), calculated from its rate constant of 12.76X10-3 sec-1(4), which suggests that vapor-phase dimethylcarbamoyl chloride will rapidly hydrolyze in fog and rain(SRC).

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=79-44-7]

PRECAUTIONS FOR "CARCINOGENS": Whenever medical surveillance is indicated, in particular when exposure to a carcinogen has occurred, ad hoc decisions should be taken concerning ... /cytogenetic and/or other/ tests that might become useful or mandatory. /Chemical Carcinogens/

ONE CASE OF EYE IRRITATION & ONE OF LIVER DISTURBANCES HAVE BEEN OBSERVED IN WORKERS EXPOSED TO DIMETHYLCARBAMOYL CHLORIDE.

NO CHROMOSOMAL ABERRATION WAS REPORTED IN 10 WORKERS EXPOSED TO THIS CMPD FOR 4-17 YEARS.

AN ESTIMATE OF TOTAL NUMBER OF WORKERS AT RISK OF DMCC EXPOSURE, MADE IN 1976, WAS < 200. THIS DID NOT INCLUDE POTENTIAL EXPOSURES TO DMCC FORMED IN SIDE REACTIONS DURING THE SYNTHESIS OF OTHER PRODUCTS. NO CASES OF HUMAN CANCER ATTRIBUTABLE TO DMCC HAVE BEEN REPORTED. DUE TO HIGH TOXICITY, HOWEVER, EXPOSURES HAVE APPARENTLY BEEN WELL CONTROLLED.

NO CANCER DEATHS (OUT OF A TOTAL OF SIX DEATHS) OR X-RAY INDICATIONS OF LUNG CANCER WERE REPORTED IN AN INVESTIGATION OF 39 DMCC PRODUCTION WORKERS...26 PROCESSING WORKERS & 42 EX-WORKERS, AGED 17-65 & EXPOSED FOR PERIODS RANGING FROM 6 MO TO 12 YR.

Chromosomal analysis of peripheral lymphocytes from 10 people who had been occupationally exposed to dimethylcarbamoyl chloride (and diethylcarbamoyl chloride) for periods ranging from 4 to 17 years showed differences in the frequency of chromosomal aberrations (inclusive and exclusive gaps), when compared with a control group of 10 people matched for age, although statistical evaluation revealed no significant increase.

U097; As stipulated in 40 CFR 261.33, when dimethylcarbamoyl chloride, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Dimethyl carbamoyl chloride is included on this list.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).