2-Amino-5-chloropyridine

HCID 66174CAS 1072-98-6
Substructure searchFind similar structures

Basic information

Standard SMILES
Nc1ccc(Cl)cn1
InChIKey
MAXBVGJEFDMHNV-UHFFFAOYSA-N
Molecular formula
C5H5ClN2
Average molar mass
128.56 g/mol
Monoisotopic mass
128.01412584

Overview

structure given in first source

Names & identifiers

Preferred name
2-Amino-5-chloropyridine
IUPAC
5-chloropyridin-2-amine
English name
2-Amino-5-chloropyridine
Molecular formula
C5H5ClN2
Molecular weight
128.56

Names & synonyms

2-Amino-5-chloropyridine1072-98-65-Chloro-2-pyridinamine2-Pyridinamine, 5-chloro-NSC-26283J8TAP6NFD4DTXSID0073247RP-26695RefChem:464572DTXCID8033063214-020-45-chloropyridin-2-amine
Show more names
80.8AKOS 91155TIMTEC-BB SBB0000595-Chlor-2-pyridylamin5-CHLORO-A-PYRIDYLAMINE2-Amino-5-Cloropyridine
5-Chloro-2-pyridylamine5-Chloro-2-aminopyridinePyridine, 2-amino-5-chloro-MFCD000063245-chloropyridin-2-ylamineA1I732-amino-5-chloro pyridine5-chloro-pyridin-2-ylamine

Database identifiers

CAS
1072-98-6
PubChem CID
66174
DTXSID
DTXSID0073247
UNII
J8TAP6NFD4
EC Number
214-020-4
Nikkaji
J31.385H

Properties

Computed structural properties

XLogP
1.1
Topological polar surface area
38.9 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
2
Rotatable bonds
0
Heavy atoms
8

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Pyridines
SpringerMaterials PropertiesNuclear quadrupole resonance spectroscopy
Physical DescriptionBeige crystalline solid; [Sigma-Aldrich MSDS]

Physicochemical properties

Melting point
135 · 135-138 °C (lit.)
Boiling point
127 · 127-128 °C/11 mmHg (lit.)
Density
1.2417 · 1.2417 (rough estimate)
refractive index
1.511 · 1.5110 (estimate)
Flash point
160 °C · 160 °C
storage temp.
2 · 2-8°C

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 63 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 2 items

Status: Active Update: 05-06-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/18254

2-Pyridinamine, 5-chloro-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryMay cause irritation; Harmful by ingestion; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesAcute Tox. 4 (100%)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
hs_code
29333999
risk_code
22-36/37/38
Signal word
Warning
Symbol(GHS)
GHS07

Chemistry & industry

Applications

Uses5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海泰矶林实业有限公司02150630626 17717886015 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

Related reactions

427 records
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Linked notes

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