Pyridine → 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.N1C=CC=CC=1.[Br:15][CH2:16][C:17](Br)=[O:18]>C1(C)C=CC=CC=1>[Br:15][CH2:16][C:17]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)=[O:18]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.
Workup
- additionwere added dropwise under ice cooling
- customAfter 2 h the precipitate was isolated by filtration
- customrecrystallized from toluene
- customto yield a white solid
Sources & evidence
- ORD record
- ord-31ec5a5ff49240e090abf794e19ea941
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07741341B2
Reaction notes
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