Lithium iodide (HCID 66321)

Names & identifiers

Preferred name: Lithium iodide
IUPAC: lithium iodide
English name: Lithium iodide anhydrous
Molecular formula: ILi
Molecular weight: 133.85

Names & synonyms

Lithium iodideLithium monoiodideLithium iodide (LiI)UNII-S6K2XET783S6K2XET783EINECS 233-822-5LITHIUM IODIDE [MI]DTXSID30908580RefChem:153730DTXCID301337657233-822-510377-51-2

Show more names

LiILithiumiodidTenephrolLithiumjodidithium iodideIodide lithiuMlithiumiodide(lii)lithiumiodide(bpc)

lithiumiodideLithium iodide, anhydrouslithium;iodideMFCD00011092Lithium iodide (6LiI)lLithiumiodid21752-61-4LiI.xH2O

Database identifiers

CAS: 10377-51-2、21752-61-4、29911-74-8
PubChem CID: 66321
DTXSID: DTXSID30908580
UNII: S6K2XET783
EC Number: 233-822-5、244-572-1
Nikkaji: J43.854E

Properties

Computed structural properties

Topological polar surface area: 0 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 2
Formal charge: 0
Complexity: 2

Experimental & physicochemical properties

Density4.06 @25 °C

Boiling Point1171 °C @760 [mm Hg]

Physical DescriptionTrihydrate: White, extremely hygroscopic solid; Soluble in water; [Hawley] White, light yellow, or pink odorless powder; Soluble in water; [MSDSonline]

Physicochemical properties

Melting point: 446 °C · 446 °C(lit.)
Boiling point: 1171 °C · 1171 °C
Density: 3.49 g/mL · 3.49 g/mL at 25 °C(lit.)
bulk density: 1000 kg/m3 · 1000kg/m3
refractive index: 1.955 · 1.955
Flash point: 1170 · 1170-1190°C
storage temp.: 30 °C · Store below +30°C.
solubility: 1640 g/l · 1640g/l soluble
form: powder
color: White to yellow to beige
Specific Gravity: 4.076 · 4.076
Water Solubility: Soluble in water, ethanol and acetone.
Specific Heat Capacity: 0.38 J/ · Cp(crystal): 0.38 J/(g·K), at 25℃
Sensitive: Hygroscopic
Merck: 14 · 14,5535
Stability: hygroscopic
Major Application: battery precursorscatalystsmaterial synthesis precursor
InChI: 1S/HI.Li/h1H;/q;+1/p-1
InChIKey: HSZCZNFXUDYRKD-UHFFFAOYSA-M
SMILES: [Li+].[I-]
Indirect Additives used in Food Contact Substances: LITHIUM IODIDE
FDA 21 CFR: 178.201 · 178.2010
CAS DataBase Reference: 10377 · 10377-51-2(CAS DataBase Reference)
FDA UNII: 6 K2XET783 · S6K2XET783
EPA Substance Registry System: Lithium iodide (10377-51-2)
UNSPSC Code: 12352302 · 12352302
NACRES: 23 · NA.23
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319
Precautionary statements: 264 · P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/38-36/37/38-22
Safety Statements: 26 · 26-37/39
WGK Germany: 1 · 1
F: 3 · 3-8-10-23
TSCA: TSCA listed
HS Code: 2827 · 2827 60 00
Storage Class: 11 · 11 - Combustible Solids
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 17.2% (43 of 250) of reports.

Warning

H302 (14%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (67.2%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (72.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (47.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H400 (44%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 250 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 43 of 250 reports by companies.；There are 11 notifications provided by 207 of 250 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 3 items

Chemical: Lithium iodide (LiI)

Status: Active Update: 25-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/34023

Lithium iodide (LiI): Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Lithium iodide (LiI): Human health tier I assessment

Hazards SummaryAn irritant; [MSDSonline] See Iodine for the TLV of Iodides.

Hazard Classes and Categories · 2 items

Skin Irrit. 2 (100%)；Eye Irrit. 2 (100%)

Acute Tox. 4 (14%)；Skin Irrit. 2 (67.2%)；Eye Irrit. 2 (72.4%)；STOT SE 3 (47.6%)；Aquatic Acute 1 (44%)

Safety & protection

Threshold Limit Values (TLV)0.01 [ppm], inhalable fraction and vapor (iodides)

Protective Action Criteria (PAC) · 3 items

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

Toxicology

Adverse EffectsNeurotoxin - Other CNS neurotoxin；Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.

Regulatory information

Regulatory Information · 3 items

Chemical: Lithium iodide (LiI)

Status: Active Update: 25-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/34023

Lithium iodide (LiI): Does not have an individual approval but may be used under an appropriate group standard

Safety data

F: 3-8-10-23
PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 1
tsca: TSCA listed
hs_code: 2827 60 00
risk_code: 36/38-36/37/38-22
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-37/39
Storage Class: 11 - Combustible Solids
Hazard statements: H315-H319
REACH Registrations: Active
Precautionary statements: P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313

Chemistry & industry

Uses & manufacturing

Uses · 2 items

Used in photography; [Merck Index] Trihydrate: Used in air conditioning and as a catalyst; [Hawley] Used in organic synthesis; [Ullmann]

Photographic Processing [Category: Other]

General Manufacturing Information · 2 items

Lithium iodide (LiI): ACTIVE

Lithium iodide (6LiI): ACTIVE

Applications · 5 items

DescriptionLithium iodide (chemical formula: LiI) is the compound of lithium and iodine. It can be used as an electrolyte in high-temperature batteries, long-life batteries which is required, e.g. by artificial pacemaker as well as in the electrolyte of dye-sensitized solar cells. In organic synthesis, it can be used for C-O bonds cleavage such as converting methyl esters to carboxylic acids. In addition, it can be used as a radio contrast agent for X-ray computed tomography imaging studies.

UsesLithium iodide can be used for the catalytic dehydrogenation of hydrocarbons. Oxidation of lithium iodide yields iodine which reacts with the hydrocarbon to form an organic iodide. The intermediate is dehydroiodinated to yield an olefin.For example, butane may be converted to butadiene.

UsesControls regioselectivity in palladium catalyzed allylic alkylation reactions.1

UsesIt is used as a absorbent in refrigeration process, as a catalyst, and in photography. It is also useful for organic synthesis, pessat iodination, cleavage of esters, ethers, epoxides, decarboethoxylation, carbonylation, and aldol condensation. It is used for manufacturing medicines and mineral waters. It is used in electochemicstry and redox reactions. Lithium iodide is also a catalyzed conjugate addition reaction of β-dicarbonyl compounds. It is also useful for tetrathioquinodimethane.

UsesControls regioselectivity in palladium-catalyzed allylic alkylation reactions.

Preparation methods · 2 items

PreparationThe laboratory preparation of lithium iodide is carried out in much the same way as the industrial preparation. Lithium iodide is prepared by the reaction of lithium hydroxide monohydrate or lithium carbonate with hydriodic acid, which may be prepared in situ by the reduction of iodine. The iodide is usually not isolated as the anhydrous material but is used as a solution or as the solid lithium iodide trihydrate. Hydriodic acid may be prepared by the reaction of hydrogen sulfide and iodine. The hydriodic acid solution must be kept under an inert atmosphere to prevent air oxidation to iodine. After combination of the acid with the lithium compounds, the solution may be evaporated to yield lithium iodide trihydrate, LiI· 3H20. The anhydrous material may be made by extremely careful dehydration of the trihydrate under vacuum and with slow heating. The lithium iodide or its trihydrate must be handled under an inert atmosphere to avoid oxidation of the iodide ion to iodine.

PreparationThe trihydrate salt is obtained by neutralization of lithium hydroxide or lithium carbonate solution with pure hydriodic acid followed by concentration of the solution for crystallization: LiOH + HI → LiI + H2O When heated in a vacuum, the trihydrate dehydrates to anhydrous salt.