Dicumyl peroxide

Excerpt from ERG Guide 145 [Organic Peroxides (Heat and Contamination Sensitive)]:

Use water spray, powder, foam, carbon dioxide.

Fresh air, rest.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Sweep up and shovel. Contain spillage, and then collect with an electrically protected vacuum cleaner or by wetbrushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal. Contain spillage, pick up with an electrically protected vacuum cleaner or by wet-brushing and transfer to a container for disposal according to local regulations.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product.

Remove all ignition sources. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment. Personal protection: P2 filter respirator for harmful particles.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed. Keep away from sources of ignition - No smoking. Keep away from heat and sources of ignition.

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

For more Preventive Measures (Complete) data for Dicumyl peroxide (6 total), please visit the HSDB record page.

Changes in the nasal mucosa after exposure to dicumyl peroxide ... were studied in rabbits. Albino Swedish rabbits were exposed to a mixture of fine polyethylene, ... dicumyl peroxide and an antioxidant or to dicumyl peroxide. Both were applied to the right nostril 3 times a day for 5 days per week at a concentration of 10 or 25 ppm in a quantity equal to 50 microliters of solution. Animals were exposed for 4 weeks and allowed to recover for 8 weeks with periodic examinations beginning at 1 hr. Signs of local irritation or damage were observed. Biopsies of the nasal mucosa were studied by light and transmission electron microscopy and by scanning microscopy. After 1 hr an increased amount of mucus containing red blood cells were seen. After 1 week exposure to either 10 ppm dicumylperoxide or 25 ppm dust an increased number of blood vessels was seen in some animals and aggregates of mucus with erythrocytes were found in all animals. At 1 month there were visible blood vessels on the medial and lateral sides of the nasal cavity not seen in unexposed rabbits. Exposure to dust at 10 ppm for 1 month did not result in any apparent changes in the mucosa. After instillation of dicumyl peroxide or the dust at 25 ppm for 1 month and a 2 month recovery, visible blood vessels were still observed and there was incr crusting and mucus in the nasal cavities of all rabbits. Scanning electron microscopy showed distortion of many cilia beginning as early as 1 hr after exposure. At 5 days areas lacking cilia but still covered with microvilli and areas with clusters of goblet cells appeared. Changes in the mucosa were more pronounced at 1 month with scattered islands without cilia in the mucosal carpet. Only partial recovery was apparent at 2 months after exposure terminated. ...

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 322,900(SRC), determined from a structure estimation method(2), indicates that dicumyl peroxide is expected to be immobile in soil(SRC). Volatilization of dicumyl peroxide from moist soil surfaces is expected(SRC) given an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(2). However, adsorption to soil is expected to attenuate volatilization(SRC). Dicumyl peroxide is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 7.5X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Based on a 0% Theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test(3), biodegradation of dicumyl peroxide is not expected to be an important enviornmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 322,900(SRC), determined from a structure estimation method(2), indicates that dicumyl peroxide is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.4X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 37 hours and 16 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 21 years when adsorption is considered(4). According to a classification scheme(5), BCFs of 137-1470 measured in carp(6), suggest bioconcentration in aquatic organisms is high to very high. Based on a 0% Theoretical BOD in 4 weeks using an activated sludge inoculum in the Japanese MITI test(6), biodegradation of dicumyl peroxide is not expected to be an important enviornmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dicumyl peroxide, which has an estimated vapor pressure of 7.5X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dicumyl peroxide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 42 hours(SRC), calculated from its rate constant of 9.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase dicumyl peroxide may be removed from the air by wet and dry deposition(SRC). Dicumyl peroxide has the potential to photolyze directly from natural sunlight based on UV absorption bands that extend beyond 290 nm(3).

IDENTIFICATION AND USE: Dicumyl peroxide is a pale yellow to white granular solid. It is used as a polymerization catalyst and vulcanizing agent. HUMAN STUDIES: Organic peroxides in contact with skin can cause irritation and even burns. A case of occupational asthma related to dicumyl peroxide has been reported. Otorhinolaryngologic examination revealed upper respiratory tract diseases in 33.3% of the workers exposed to dicumyl peroxide. ANIMAL STUDIES: In the most severe injuries induced in rabbit eyes there has been great chemosis and formation of gas bubbles in the conjunctiva, cornea, and anterior chamber. Conjunctiva has become necrotic and the cornea opaque. Dicumyl peroxide was a weak tumor promoter despite its high activity in inducing hyperplasia. Tumor promotion activity of organic peroxides is associated with free radical generation. Dicumyl peroxide causes more than 50% of malformed embryos at any dose in white Leghorn chicken embryos. Dicumyl peroxide gave inconsistent results when tested for mutagenicity using Salmonella typhimurium tester strains TA100 and TA104.

Cough. Sore throat.

Redness.

Redness.

The following link will take the user to the National Toxicology Program (NTP) Test Status of Agents Search page, which tabulates the results and current status of tests such as "Short-Term Toxicity Studies", "Long-term Carcinogenicity Studies", "Developmental Studies", "Genetic Toxicology Studies", etc., performed with this chemical. Testing status for dicumyl peroxide is available.[Available from, as of November 3, 2017: https://ntpsearch.niehs.nih.gov/?e=True&ContentType=Testing+Status]

EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPA; ICSS Dashboard Application; Available from, as of September 21, 2017: http://actor.epa.gov/dashboard/]

Using a structure estimation method based on molecular connectivity indices(1), the Koc of dicumyl peroxide can be estimated to be 322,900(SRC). According to a classification scheme(2), this estimated Koc value suggests that dicumyl peroxide is expected to be immobile in soil(SRC).

/SIGNS AND SYMPTOMS/ Organic peroxides in contact with skin can cause irritation and even burns. /Organic peroxides/

/CASE REPORTS/ We report the case of an electrical cable repairer who presented with symptoms suggestive of occupational asthma. A supervised workplace challenge test confirmed this diagnosis and laboratory challenge studies implicated heated polyethylene repair tape containing the chemical cross-linking agent dicumyl peroxide as the cause. Similar cross-linking processes are widely used in the cable manufacturing industry and the possibility of occupational asthma occurring in other settings may need to be considered.

/EPIDEMIOLOGY STUDIES/ The effect of dicumyl peroxide (DP) on the skin and upper respiratory tract (URT) was studied in 57 workers at an ... electro-cable plant. ... The dermatologic examination disclosed in 21.5% of the workers a variety of skin /conditions/; 5.3% had /serious/ skin diseases: in 3.5% of allergic nature and in 1.8% irritative contact dermatitides. Otorhinolaryngologic examination revealed upper respiratory tract diseases in 33.3% of the workers. ...

/EPIDEMIOLOGY STUDIES/ Workers (18) exposed to dicumyl peroxide in a chemical plant were subjected to examination of the nose by rhinoscopy, mucociliary function test and rhinomanometry. Eight other workers at the plant and 20 hospital workers were used as controls. The mucociliary function and nasal air flow were the same in subjects exposed and those not exposed to peroxide. Of the workers exposed to dicumyl peroxide had visible blood vessels in the mucosa on the anterior part of the nasal septum. Only 2 persons in the other groups had visible blood vessels. Both had a common cold at the time of the examination. ...

/EPIDEMIOLOGY STUDIES/ In the production of cross-linked polyethylene in the air of the working environment above the norm concentrations of acetophenon, dicumyl peroxide and antioxidant are established, which create unfavorable working conditions. During clinical and laboratory examinations of 55 workers, engaged in the production of cross-linked polyethylene, are registered subjective complaints from the irritating effect of the chemical noxae on the mucous membranes and skin. Methemoglobinaemia is found in 4 workers. There are deviations in the functional state of the liver (transaminase, APh, GGTP and triglycerides) in the group "maintaining staff". The same workers have also increased quantity of metabolite hippuric acid in the urine. On the grounds of the results, the group "maintaining staff" is determined as risk group. Recommendations are made for follow-up care and work in controlled parameters of the working environment.