Basic information
- CAS
38260-01-4- Standard SMILES
Cl.Cl.NCCNCCNCCN- InChIKey
WYHIICXRPHEJKI-UHFFFAOYSA-N- Molecular formula
- C6H20Cl2N4
- Average molar mass
- 219.15 g/mol
- Monoisotopic mass
- 218.106502
Overview
Trientine Hydrochloride can cause developmental toxicity according to state or federal government labeling requirements.
Names & identifiers
- Preferred name
- Trientine Hydrochloride
- IUPAC
- N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine;dihydrochloride
- English name
- Triethylenetetramine Dihydrochloride
- Molecular formula
- C6H20Cl2N4
- Molecular weight
- 219.16
Names & synonyms
38260-01-4Trientine hydrochlorideTriethylenetetramine dihydrochlorideSyprineTrientine DihydrochlorideMetaliteMK-06811,2-Ethanediamine, N,N'-bis(2-aminoethyl)-, dihydrochlorideTriethylene tetramine dihydrochlorideCLOVIQUEHC3NX54582NSC-759164
Show more names
Trientine HCLTRIENETJA-250Triene2HClTrientine chloridetriendihydrochloridetrientinehydrochloride
N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochlorideDTXSID2057863N,N-bis (2-aminoethyl)-1,2-ethanediamine DihydrochlorideRefChem:57637DTXCID8031651253-854-3N1,N1'-(ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochlorideN,N'-Bis(2-aminoethyl)-1,2-ethanediamine dihydrochloride
Database identifiers
- CAS
38260-01-4- PubChem CID
- 71433
- DTXSID
DTXSID2057863- ChEMBL
Properties
Computed structural properties
- Topological polar surface area
- 76.1 Ų
- Hydrogen bond donors
- 6
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 7
- Heavy atoms
- 12
- Formal charge
- 0
- Complexity
- 49.7
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine
FDA approved drugs -> Active ingredient
Collision Cross Section138.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 120 · 120-125 °C (dec.)
- storage temp.
- 2 · 2-8°C
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 50 mg/mL, · water: 50mg/mL, clear to slightly hazy
- BRN
- 5961763 · 5961763
- Cosmetics Ingredients Functions
- CHELATING
- InChI
- 1S/C6H18N4.2ClH/c7-1-3-9-5-6-10-4-2-8;;/h9-10H,1-8H2;2*1H
- InChIKey
- WYHIICXRPHEJKI-UHFFFAOYSA-N
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H315 (97.5%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 40 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationHazard Traits - Developmental Toxicity
Hazard Classes and CategoriesSkin Irrit. 2 (97.5%)
Toxicology
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Trientine hydrochloride
vNo-DILI-concern
1
No match
DOI:10.1016/j.drudis.2016.02.015
Safety data
- F
- 3
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 2
- rtecs
- KH8587085
- hs_code
- 2921290055
- risk_code
- 36/37/38
- Signal word
- Danger
- Symbol(GHS)
- GHS05,GHS07
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
TRIENTINE HYDROCHLORIDE
Copper Chelating Activity [MoA]; Copper Chelator [EPC]; Metal Chelating Activity [MoA]; Metal Chelator [EPC]
MeSH Pharmacological ClassificationChemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
Applications
DescriptionTrientine hydrochloride is a copper chelating agent recommended for the treatment of Wilson's Disease, especially in patients intolerant of penicillamine therapy. Unlike the latter agent, trientine is not indicated in cystinuria or rheumatoid arthritis.
UsesTriethylenetetramine Hydrochloride is a selective CuII-chelator; crosslinking agent. Triethylenetetramine is undergoing trials for the treatment of heart failure in patients with diabetes.
Usesantibacterial
UsesAs thermosetting resin; epoxy curing agent; lubricating oil additive; analytical reagent for Cu, Ni.
General DescriptionPharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Trientine Hydrochloride is administered for relief of symptoms of Wilson′s disease for penicillamine intolerance, hence is employed as an oral medication for the treatment of an inherited defect in copper metabolism.
Upstream & downstream products
Upstream raw materials
Related reactions
4 records
Compound notes
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