Basic information
- Standard SMILES
O.O.O=C([O-])CC(O)(CC(=O)[O-])C(=O)[O-].[Na+].[Na+].[Na+]- InChIKey
NLJMYIDDQXHKNR-UHFFFAOYSA-K- Molecular formula
- C6H9Na3O9
- Average molar mass
- 294.1 g/mol
- Monoisotopic mass
- 293.99396471
Overview
Sodium citrate dihydrate is the dihydrate of trisodium citrate. It has a role as an anticoagulant. It contains a sodium citrate.
Names & identifiers
- Preferred name
- Sodium Citrate Dihydrate
- IUPAC
- trisodium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate
- English name
- Trisodium citrate dihydrate
- Molecular formula
- C6H9Na3O9
- Molecular weight
- 294.1
Names & synonyms
Trisodium citrate dihydrateSodium citrate dihydrate6132-04-3Sodium citrate hydrateB22547B95KCitric acid, trisodium salt, dihydrateSodium citrate hydrousEmetrol Chewables OrangeNauzeneDTXSID1049437CHEBI:32142N-1560
Show more names
CITRIC ACID MONOSODIUM CITRATE TRIBASIC DIHYDRATETRI-SODIUM CITRATE DIHYDRATESODIUM CITRATE, DIHYDRATESodiuM Citrate (AS)SODIUM CITRATE TRISODIUM SALT DIHYDRATENATRII CITRASTRI-SODIUM CITRATE 2H2OSodiumCitrateTribasicUspACIDUM CITRICUM MONOHYDRICUM
Natrii citras, dehydrateAnticoagulant Sodium CitrateTricitrasolEmetrol PowderEmetrol ChewablesNauzene ChewablesCVS HealthRefChem:6335
Database identifiers
- CAS
6132-04-3- PubChem CID
- 71474
- DTXSID
DTXSID1049437- ChEBI
CHEBI:32142- UNII
- B22547B95K
- EC Number
- 612-118-5
Properties
Computed structural properties
- Topological polar surface area
- 143 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 9
- Rotatable bonds
- 2
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 211
Experimental & physicochemical properties
Chemical ClassesMetals -> Organic Acids, Metal Salts
SolubilitySolubility in water, g/100ml: 77
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
Decomposition150 °C
Physical Description
White odorless solid; [Merck Index] Colorless odorless crystalline powder; [Alfa Aesar MSDS]
WHITE SOLID IN VARIOUS FORMS.
Physicochemical properties
- Melting point
- 300 °C · >300 °C(lit.)
- Density
- 1.76 · 1.76
- bulk density
- 600 kg/m3 · 600kg/m3
- FEMA
- 3026 · 3026 | SODIUM CITRATE
- Flash point
- 173.9 °C · 173.9 °C
- storage temp.
- 5 °C · Store at +5°C to +30°C.
- solubility
- 2 O: · H2O: 100 mg/mL
- form
- powder
- pka
- 6.4 · 6.40
- color
- white
- Odor
- Odorless
- PH Range
- 7.5 · 7.5 - 9 at 29.4 g/l at 25 °C
- PH
- 7 · 7.0-9.0 (25℃, 50mg/mL in H2O)
- biological source
- synthetic
- Water Solubility
- 720 g/L · 720 g/L (25 ºC)
- λmax
- 260 nm · λ: 260 nm Amax: 0.01λ: 280 nm Amax: 0.01
- Merck
- 14 · 14,8602
- BRN
- 6104939 · 6104939
- Stability
- Stable. Incompatible with bases, reducing agents, oxidizing agents.
- Cosmetics Ingredients Functions
- CHELATINGFRAGRANCEBUFFERING
- InChI
- 1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3
- InChIKey
- NLJMYIDDQXHKNR-UHFFFAOYSA-K
- SMILES
- O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
- LogP
- -1.72 · -1.72
- CAS DataBase Reference
- 6132 · 6132-04-3(CAS DataBase Reference)
- FDA UNII
- 22547 B95K · B22547B95K
- EPA Substance Registry System
- 1 · 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate (6132-04-3)
- Absorption
- 0.015 at · ≤0.015 at 260nm≤0.015 at 280nm
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 25 · NA.25
- Symbol(GHS)
- 5 · GHS05,GHS07
- Signal word
- Warning
- Hazard statements
- 318 · H318-H319
- Precautionary statements
- 264 · P264-P280i-P305+P351+P338-P337+P313-P310a
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- Hazard Codes
- Xi
- Risk Statements
- 37 · 37/38-41-36/37/38
- Safety Statements
- 26 · 26-36/37/39-24/25-36
- WGK Germany
- 1 · 1
- RTECS
- 7810000 · GE7810000
- TSCA
- Yes
- HS Code
- 2918 · 2918 15 00
- Storage Class
- 11 · 11 - Combustible Solids
- Toxicity
- 50 orally · LD50 orally in Rabbit: > 8000 mg/kg
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 97% (520 of 536) of all reports.
Not Classified
Aggregated GHS information provided per 536 reports by companies from 4 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate
Trisodium citrate dihydrate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate: Human health tier I assessment
Fire HazardsCombustible.
Hazards SummaryAn eye and respiratory tract irritant; [ICSC] May cause irritation; [Alfa Aesar MSDS] See Sodium citrate, anhydrous.
EPA Safer ChemicalChemical: Sodium citrate, dihydrate
Chemical DangersThe solution in water is a weak base.
Hazard Classes and CategoriesNot Classified
Safety & protection
Fire FightingUse water spray, powder.
First Aid Measures
Fresh air, rest.
Rinse and then wash skin with water and soap.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth.
Spillage DisposalSweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.
Eye PreventionWear safety spectacles.
Fire PreventionNO open flames.
Inhalation RiskEvaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed.
Ingestion PreventionDo not eat, drink, or smoke during work.
Inhalation PreventionUse ventilation (not if powder).
Effects of Short Term ExposureThe substance is irritating to the eyes and respiratory tract.
Toxicology
Exposure RoutesThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Signs and Symptoms
Cough. Sore throat.
Redness.
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 1
- tsca
- Yes
- rtecs
- GE7810000
- hs_code
- 2918 15 00
- Toxicity
- LD50 orally in Rabbit: > 8000 mg/kg
- risk_code
- 37/38-41-36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS05,GHS07
- hazard_code
- Xi
- safety_code
- 26-36/37/39-24/25-36
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H318-H319
- Precautionary statements
- P264-P280i-P305+P351+P338-P337+P313-P310a
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
SODIUM CITRATE DIHYDRATE
Anti-coagulant [EPC]; Acidifying Activity [MoA]; Calculi Dissolution Agent [EPC]; Decreased Coagulation Factor Activity [PE]; Calcium Chelating Activity [MoA]
TRISODIUM CITRATE DIHYDRATE
Anti-coagulant [EPC]; Acidifying Activity [MoA]; Calculi Dissolution Agent [EPC]; Calcium Chelating Activity [MoA]; Decreased Coagulation Factor Activity [PE]
MeSH Pharmacological Classification
Agents that prevent BLOOD CLOTTING.
A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.
Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.
Uses & manufacturing
Uses
Used in blood collection (anticoagulant), photography, and food production (sequestering agent, emulsifier, and acidulant); [Merck Index] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]
Photographic Processing [Category: Other]
Household ProductsInformation on 307 consumer products that contain Sodium citrate dihydrate in the following categories is provided:
Use Classification
EPA Safer Chemical Functional Use Classes -> Chelating Agents;Preservatives and Antioxidants;Processing Aids and Additives
Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern
Applications
UsesIt can be used as Ph adjusting agents and emulsifying enhancers applied to jam, candy, jelly and ice cream; its combination with citric acid has an effect of alleviating tour; it also has effects on forming complex with metal ions. China rules that it can be applied to various types of food with appropriate usage according to the absolute necessity.It can be used as a food additive, as complex agent and buffering agent in electroplating industry; at the field of pharmaceutical industry, it is used for the manufacturing of anti-clotting drugs; and used as the detergent additives in light industry.It is used as the analysis agents used for chromatography analysis and can also used for preparing bacterial culture medium; moreover, it can also be applied into pharmaceutical industry.The product can be used for the flavoring processing of food, as stabilizers, buffers and deputy complex-forming agents in non-toxic electroplating industry; at pharmaceutical industry, it is used as anti-clotting agent, phlegm drugs and diuretics drugs. It can also be used in brewing, injection, newspaper and movies medicines.
UsesAnticoagulant for collection of blood. In photography; as sequestering agent to remove trace metals; as emulsifier, acidulant and sequestrant in foods.
UsesAn anticoagulant also used as a biological buffer
UsesTrisodium citrate dihydrate, is widely applied in food, beverages and fillers as a buffering, sequestering or an emulsifying agent. It used as an anticoagulant in blood transfusions, osmotic laxative, functional fluids, solvents cleaning, furnishing care products, laundry dishwashing products and cleaning automobile radiators.
UsesSodium citrate is chiefly used as a food additive, usually for flavor or as a preservative.
General DescriptionSodium citrate tribasic dihydrate is the tribasic dihydrate sodium salt of citric acid.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers50 total
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Additional notes
DefinitionChEBI: The dihydrate of trisodium citrate.
Related reactions
38 records
Linked notes
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