2-Methyltetrahydrofuran (HCID 7301)

Overview

Methyltetrahydrofuran appears as a colorless liquid with an ether-like odor. Less dense than water. Vapors heavier than air. Used to make other chemicals and as a solvent.

Names & identifiers

Preferred name: 2-Methyltetrahydrofuran
IUPAC: 2-methyloxolane
English name: methyltetrahydrofuran
Molecular formula: C5H10O
Molecular weight: 86.13

Names & synonyms

2-METHYLTETRAHYDROFURAN96-47-92-MethyloxolaneTetrahydrosylvanTetrahydro-2-methylfuranFuran, tetrahydro-2-methyl-MTHFDTXSID9030258FCD0VD8ALFNSC-2115DTXCID7010258RefChem:88394

Show more names

DIMETHYLTETRAHYDROFURANTetrahydromethylfuran2-methyl-furamethyltetrahydrofuran

202-507-4MethyltetrahydrofuranFuran, 2-methyl-tetrahydro-25265-68-32-MeTHFFuran, tetrahydromethyl-MFCD000053672-methyl tetrahydrofuran

Database identifiers

CAS: 25265-68-3、96-47-9
PubChem CID: 7301
DTXSID: DTXSID9030258
ChEMBL: CHEMBL1580503
UNII: FCD0VD8ALF
EC Number: 202-507-4、246-769-8
Nikkaji: J49.588C

Properties

Computed structural properties

XLogP: 1
Topological polar surface area: 9.2 Å²
Hydrogen bond donors: 0
Hydrogen bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 6
Formal charge: 0
Complexity: 43.2

Experimental & physicochemical properties

Chemical ClassesFlammable agents - 3rd degree

SolventsSolvents -> Ethers (<C12)

Density0.853 @ 20°C

Boiling Point80 °C @760 [mm Hg]

Vapor Pressure97.3 [mmHg]

Physical Description · 3 items

Methyltetrahydrofuran appears as a colorless liquid with an ether-like odor. Less dense than water. Vapors heavier than air. Used to make other chemicals and as a solvent.

Liquid

Clear, colorless to yellow liquid with a mildly irritating odor of ether; [NTP: CSWG]

Physicochemical properties

Boiling point: 77 · 77-78 °C
EPA Substance Registry System: Furan, tetrahydromethyl- (25265-68-3)

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H225 (85.6%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 439 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

Hazard information

Regulatory Information · 5 items

Chemical: Furan, tetrahydro-2-methyl-

Furan, tetrahydro-2-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Furan, tetrahydro-2-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 28-02-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13699

Furan, tetrahydro-2-methyl-: HSNO Approval: HSR001202 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelFlammable Liquid

Fire Hazards · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Health Hazards · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

· Inhalation or contact with material may irritate or burn skin and eyes.

Hazards SummaryStabilized with 0.025% BHT (CAS# 128-37-0); An eye irritant; [Sigma-Aldrich MSDS] See Tetrahydrofuran.

DOT ID and Guide2536 127

Safety & protection

Fire FightingExcerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

Accidental Release Measures · 2 items

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.

First Aid · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

General First Aid:

Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).

Nonfire Spill ResponseExcerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

Isolation and Evacuation · 2 items

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]:

Immediate precautionary measure

Toxicology

Adverse EffectsNeurotoxin - Acute solvent syndrome

Toxicity DataLC50 (rat) = 6,000 ppm/4hr

Chemistry & industry

Uses & manufacturing

Uses · 2 items

Used as a specialty solvent and as a reactant in chemical manufacture, as a solvent for organometallic reagents, and for electrolytic solutions in lithium batteries; Also recently being used in gasoline alternative P-series fuels (blends of ethanol, methyltetrahydrofurans, and pentanes); [NTP: CSWG]

Battery Manufacturing [Category: Industry]

U.S. Production2023: 1,000,000 - <8,500,000 lb

Industry UsesFuel

General Manufacturing Information · 2 items

Pharmaceutical and Medicine Manufacturing

Furan, tetrahydro-2-methyl-: ACTIVE

Applications

General DescriptionA colorless liquid with an ether-like odor. Less dense than water. Flash point 12°F. Vapors heavier than air. Used to make other chemicals and as a solvent.