Arsanilic Acid

A time limited tolerance is established for residues of the plant growth regulator arsanilic acid [(4-aminophenyl) arsonic acid], in or on the following food commodities in connection with the use of the pesticide under section 5 experimental use permit. The tolerance will expire on the date specified in the following: grapefruit, 2 ppm (not to exceed 0.7 ppm total arsenic), expiration/revocation date: 2/28/01.

Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue; 2 ppm in uncooked edible by-products; & 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney; 0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

... The effects of cadmium (50 mg/kg diet) & lead (200 mg/kg) on the toxicity of arsenic administered to rats as sodium arsenate or arsanilic acid in the food (50 mg As/kg diet) /was examined/. The efficiency of food utilization was more reduced by the combination of arsenic & cadmium than by each metal alone. The combination of arsenic & cadmium also caused a greater decr in serum alkaline phosphatase levels than either metal alone. Additive effects of arsenic & lead in coproporphyrin excretion were also noted. Increased uroporphyrin excretion in rats was reported ..., when lead cadmium & arsenic were combined compared with excretion levels following exposure to arsenic alone.

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carcinogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)

Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of “pins and needles” in hands and feet. Breathing high levels of inorganic arsenic can give you a sore throat or irritated lungs. Arsenic also affects the brain, causing neurological disturbances such as headaches, confusion, and drowsiness. (A1)

ARSANILIC ACID...CONSUMPTION DOES NOT GIVE RISE TO POISONING...IN MAN...

SIMILAR TO OTHER /ANTISYPHILITIC/ DERIVATIVES OF ARSANILIC ACID, /ACETARSOL/... CAUSED OPTIC NEURITIS & OPTIC ATROPHY...GREATEST DANGER...IV INJECTION... VISION FIELDS CONTRACTED & VISION...POOR IN DIM ILLUMINATION. IN ONE...CASE, RETROLOBULAR NEURITIS WITH CENTRAL SCOTOMA FOR COLORS...AFTER 20 DAYS TREATMENT... /ACETARSOL/

HIGHLY TOXIC.

Complaints of keratosis were roughly two-fold higher than unexposed controls in female packaging workers exposed to arsanilic acid at an avg concn of 0.05 mg As/m3 and in male manufacturing workers exposed to an avg concn of 0.13 mg As/m3 in a chemical factory ... .

ARSANILIC ACID FED TO PIGS IS STORED IN TISSUES IN FORM THAT IS METABOLICALLY INERT, & ITS CONSUMPTION DOES NOT GIVE RISE TO POISONING IN LAB ANIMALS...

TURKEYS & SWINE ARE MORE SUSCEPTIBLE TO TOXIC EFFECTS THAN CHICKEN. CAUSES SLIGHT INCR IN BLOOD CLOTTING TIME IN POULTRY & SWINE. THERAPEUTIC LEVEL GIVEN TO SWINE FOR PERIODS LONGER THAN RECOMMENDED HAS CAUSED BLINDNESS.

ARSANILIC ACID FED TO PIGS FOR WK @ 15 TIMES RECOMMENDED LEVEL INDUCED TOXIC SYMPTOMS...BUT EVEN 8000 PPM WAS NOT FATAL...TOXICITY OF ARSANILIC ACID INCR IF WATER INTAKE RESTRICTED. INCORPORATED INTO RATIONS @ RATE OF 2000 OR 4000 PPM IT CAUSED CONVULSIONS IN LAMBS.

...CHRONIC POISONING...PIGS...WITH ARSANILIC ACID SHOWED PROGRESSIVE BLINDNESS, ATAXIA & PARESIS... POST MORTEM APPEARANCES...IN PIGS POISONED WITH ARSANILIC ACID THE URINARY BLADDER MAY BE GROSSLY DISTENDED.

For more Non-Human Toxicity Excerpts (Complete) data for ARSANILIC ACID (6 total), please visit the HSDB record page.

LD50 Rat oral >1000 mg/kg

LD50 Mouse ip 248 mg/kg

LD50 Mouse iv 100 mg/kg

A time limited tolerance is established for residues of the plant growth regulator arsanilic acid [(4-aminophenyl) arsonic acid], in or on the following food commodities in connection with the use of the pesticide under section 5 experimental use permit. The tolerance will expire on the date specified in the following: grapefruit, expiration/revocation date: 2/28/01.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Arsanilic acid is included on this list.

(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/

For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/

D004; A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.

(AZ) ARIZONA 10 ug/L /Arsenic/

(CT) CONNECTICUT 10 ug/l /Arsenic/