Dioctyltin dichloride

Liquid; Liquid; Other Solid

White solid; [OECD SIDS] Crystalline solid; [Alfa Aesar MSDS]

Danger

H330: Fatal if inhaled [Danger Acute toxicity, inhalation]

P203, P260, P264, P270, P271, P273, P280, P284, P304+P340, P316, P318, P319, P320, P403+P233, P405, and P501 (click each P-code to see the statement)

Danger

H314 (18.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P203, P260, P264, P270, P271, P273, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P319, P320, P321, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Chemical: Stannane, dichlorodioctyl-

Hazard Traits - Reproductive Toxicity

Stannane, dichlorodioctyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Stannane, dichlorodioctyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 19-08-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/14165

The thioglycolate ester isomers are dioctyltin bis(2-ethylhexyl thioglycolate) CAS# 15571-58-1 and dioctyltin bis(isooctyl thioglycolate) CAS# 26401-97-8; [OECD SIDS] An irritant; Toxic by ingestion, inhalation, and skin absorption; [Alfa Aesar MSDS] See Tin, organic compounds. See Trichlorooctylstannane.

Acute Tox. 2 (77.3%)

Acute toxicity (inhalation) - category 2

Acute toxicity (Inhalation: Dusts and mists) - Category 2

Repr. 1B

0.1 [mg/m3], as Sn

0.2 [mg/m3], as Sn

Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)

Though tin metal is very poorly absorbed, tin compounds may be absorbed via oral, inhalation, or dermal routes, with organotin compounds being much more readily absorbed than inorganic tin compounds. Tin may enter the bloodstream and bind to hemoglobin, where it is distributed and accumulates mainly in the kidney, liver, lung, and bone. Organotin compounds may undergo dealkylation, hydroxylation, dearylation, and oxidation catalyzed by cytochrome P-450 enzymes in the liver. The alkyl products of dealkylation are conjugated with glutathione and further metabolized to mercapturic acid derivatives. Tin and its metabolites are excreted mainly in the urine and feces. (L308)

Always produced as a mixture with monooctyltin trichloride (MOTC, CAS# 3091-25-6); Used as a heat stabilizer for polyvinyl chloride (PVC) and chlorinated PVC (CPVC) with applications including films (including indirect food contact), sheets, injection mouldings, pipes, and sidings; [OECD SIDS]

All Other Chemical Product and Preparation Manufacturing

Stannane, dichlorodioctyl-: ACTIVE