Tricine

HCID 79784CAS 5704-04-1
Substructure searchFind similar structures

Basic information

Standard SMILES
O=C(O)CNC(CO)(CO)CO
InChIKey
SEQKRHFRPICQDD-UHFFFAOYSA-N
Molecular formula
C6H13NO5
Average molar mass
179.17 g/mol
Monoisotopic mass
179.07937252

Names & identifiers

Preferred name
Tricine
IUPAC
2-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acid
English name
Tricine
Molecular formula
C6H13NO5
Molecular weight
179.17

Names & synonyms

Tricine5704-04-1N-Tris(hydroxymethyl)methylglycineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-W12LH4V8V32-((1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)amino)acetic acidNSC-3699952-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]acetic acidDTXSID1063982CHEBI:39063n-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)glycine
Show more names
TRIS-HCL BUFFER1389475TROMETHAMINE HYDROCHLORIDETicineTricine buffer, free acidTRI(HYDROXYMETHYL) AMINO METHANE HYDROCHLORIDETRIClNEn-Tricine-D8
2-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}acetic acidGlycine, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-RefChem:899271DTXCID6042159CHEBI:467602-((1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)azaniumyl)acetate227-193-6N-[Tris(hydroxymethyl)methyl]glycine

Database identifiers

CAS
5704-04-1
PubChem CID
79784
DTXSID
DTXSID1063982
ChEBI
CHEBI:39063
UNII
W12LH4V8V3
EC Number
227-193-6
Nikkaji
J135.902I

Properties

Computed structural properties

XLogP
-5.1
Topological polar surface area
110 Ų
Hydrogen bond donors
5
Hydrogen bond acceptors
6
Rotatable bonds
6
Heavy atoms
12

Experimental & physicochemical properties

Physical DescriptionSolid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]

Physicochemical properties

Melting point
186 · 186-188 °C (dec.)
Boiling point
311.69 °C · 311.69°C (rough estimate)
Density
1.05 g/mL · 1.05 g/mL at 20 °C
bulk density
500 kg/m3 · 500kg/m3
vapor pressure
0.002 · 0.002-0.004Pa at 20-25℃
refractive index
1.424 · 1.4240 (estimate)

Safety & regulation

GHS classification

GHS Classification · 3 items

This chemical does not meet GHS hazard criteria for 97.6% (121 of 124) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 121 of 124 companies (only 2.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 124 reports by companies from 4 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 121 of 124 reports by companies.；There are 3 notifications provided by 3 of 124 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 3 items

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesNot Classified

Regulatory information

Regulatory Information · 3 items

Chemical: Glycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-

Status: Active Update: 02-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/25731

Glycine, N-2-hydroxy-1,1-bis(hydroxymethyl)ethyl-: Does not have an individual approval but may be used under an appropriate group standard

Safety data

F
3
wgk
3
tsca
TSCA listed
hs_code
29052900
risk_code
36/37/38
Signal word
Warning

Chemistry & industry

Uses & manufacturing

UsesUsed as a biological buffer; [Merck Index]
General Manufacturing InformationGlycine, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-: ACTIVE
Applications · 2 items

UsesGood's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets. It is a zwitterionic amino acid commonly useful in the pH range of 7.4-8.8 and the pKa is 8.05 at 25°C. This buffer is also used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).

General DescriptionTricine and its salts are used as biological buffers to control the pH of body fluids in vitro and in vivo. It acts as a precursor for polymers, oxazolones (with carboxylic acids), and oxazolidines (with aldehydes). Trizma can serve as an alkalizing agent in treating acidosis of the blood.

Upstream & downstream products

Suppliers50 total

湖北博杰生物科技有限公司0713-2060728 15629612610
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉鹏垒生物科技有限公司15871464247 · [email protected]
怀化元研达生物技术有限责任公司18711085600 · [email protected]

Additional notes

DefinitionChEBI: N-tris(hydroxymethyl)methylglycine is a Good's buffer substance, pKa = 8.15 at 20 ℃. It is functionally related to a member of tris and a glycine. It is a tautomer of a N-tris(hydroxymethyl)methylammonioacetate.

Related reactions

9 records
New reaction record

Linked notes

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